Experimental infection of inbred BALB/c and A/J mice with Massachusetts and Brazilian strains of infectious bronchitis virus (IBV)

被引:4
|
作者
Martini, Matheus C. [2 ]
Gameiro, Jacy [3 ]
Cardoso, Tereza Cristina [4 ]
Caserta, Leonardo C. [2 ]
Gualberto, Ana Carolina M. [3 ]
Keid, Lara Borges [1 ]
Oliveira, Tricia M. F. de S. [1 ]
dos Santos, Marcia M. A. B. [3 ]
Arns, Clarice W. [2 ]
Ferreira, Helena L. [1 ]
机构
[1] FZEA USP, BR-13635900 Pirassununga, SP, Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Lab Anim Virol, BR-13083970 Campinas, SP, Brazil
[3] ICB Univ Fed Juiz de Fora, BR-36036330 Juiz De Fora, MG, Brazil
[4] UNESP Univ Estadual Paulista, Coll Vet, BR-16050680 Aracatuba, SP, Brazil
关键词
Virus; Mice; Avian; Pneumonia; RESPIRATORY SYNDROME CORONAVIRUS; AVIAN CORONAVIRUSES; IMMUNE-RESPONSES; CHICKENS; MUCOSAL;
D O I
10.1007/s00705-015-2443-x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The ability of avian coronaviruses to replicate in mice was investigated to investigate interspecies transmission. Two inbred mouse strains (BALB/c and A/J) with different genetic backgrounds were inoculated with the avian coronavirus strains Mass and BR-I and monitored for at least 10 days. Analysis of viral RNA, histopathological examinations, immunohistochemistry and serology were performed. After virus inoculation, neither clinical signs nor evident gross lesions were observed. Viral RNA, histopathological changes, and viral nucleoprotein were observed in the lung, trachea and sinus of all inoculated mice. Our study demonstrates the importance of elucidating the epidemiology of coronaviruses, including in rodents that are pests in poultry production.
引用
收藏
页码:1785 / 1790
页数:6
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