Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry

被引：133
|
作者：
Ishihama, Y [1 ]
机构：
[1] Eisai & Co Ltd, Lab Seeds Finding Technol, Tsukuba, Ibaraki 3002635, Japan
来源：
JOURNAL OF CHROMATOGRAPHY A | 2005年 / 1067卷 / 1-2期
关键词：
proteome; proteomics; NanoLC-MS/MS;
D O I：
10.1016/j.chroma.2004.10.107
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Current nano-scale liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) approaches in proteome research are reviewed from an analytical perspective. For comprehensive analysis of cellular proteins, analytical methods with higher resolution, sensitivity, and wider dynamic range are required. Miniaturized LC coupled with tandem mass spectrometry is currently one of the most versatile techniques. In this review, the current status of nanoLC-MS/MS systems as well as data management systems is addressed. In addition, the future prospects for complete proteomics are discussed. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：73 / 83
页数：11
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