Squaring the circle: circRNAs in melanoma

被引：12

作者：

Mecozzi, Nicol ^{[1
]}

Vera, Olga ^{[1
]}

Karreth, Florian A. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA

来源：

ONCOGENE | 2021年 / 40卷 / 37期

关键词：

CIRCULAR RNAS; CELL-PROLIFERATION; MALIGNANT-MELANOMA; CANCER; PROGRESSION; TRANSLATION; BIOGENESIS; REVEALS; MIR-135B-5P; EXPRESSION;

D O I：

10.1038/s41388-021-01977-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs are emerging as critical molecules in the genesis, progression, and therapy resistance of cutaneous melanoma. This includes circular RNAs (circRNAs), a class of non-coding RNAs with distinct characteristics that forms through non-canonical back-splicing. In this review, we summarize the features and functions of circRNAs and introduce the current knowledge of the roles of circRNAs in melanoma. We also highlight the various mechanisms of action of the well-studied circRNA CDR1as and describe how it acts as a melanoma tumor suppressor. We further discuss the utility of circRNAs as biomarkers, therapeutic targets, and therapeutic agents in melanoma and outline challenges that must be overcome to comprehensively characterize circRNA functions.

引用

页码：5559 / 5566

页数：8

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Olga Vera
Florian A. Karreth
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