BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk

被引：688
|
作者：
Miyazono, K
Maeda, S
Imamura, T
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan
[2] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Koto Ku, Tokyo 1358550, Japan
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 03期
关键词：
BMP; TGF-beta; serine/threonine kinase receptor; Smad; signaling cross-talk;
D O I：
10.1016/j.cytogfr.2005.01.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various proteins, including transcription factor Runx, and transmit specific signals in target cells. The recent development of DNA microarray techniques has allowed us to identify many BMP target genes. BMP signaling is modulated by various molecules, including inhibitory Smads (I-Smads). Moreover, recent findings have revealed that BMP pathways interact with other signaling pathways, and such signaling cross-talk plays pivotal roles in growth and differentiation of target cells. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：251 / 263
页数：13
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