Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case

被引：26

作者：

Schoon, Janosch ^{[1
,2
,3
]}

Geissler, Sven ^{[1
,2
,3
]}

Traeger, Juliane ^{[4
]}

Luch, Andreas ^{[5
]}

Tentschert, Jutta ^{[5
]}

Perino, Giorgio ^{[6
]}

Schulze, Frank ^{[1
]}

Duda, Georg N. ^{[1
,2
,3
]}

Perka, Carsten ^{[2
,3
,7
]}

Rakow, Anastasia ^{[7
]}

机构：

[1] Charite, Julius Wolff Inst, D-13353 Berlin, Germany

[2] Charite, Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany

[3] Charite, Berlin Brandenburg Sch Regenerat Therapies, Berlin, Germany

[4] Univ Potsdam, Inst Chem Inorgan Chem, Potsdam, Germany

[5] German Fed Inst Risk Assessment BfR, Dept Chem & Prod Safety, Berlin, Germany

[6] Hosp Special Surg, Dept Pathol & Lab Med, 535 E 70th St, New York, NY 10021 USA

[7] Charite, Ctr Musculoskeletal Surg, Berlin, Germany

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2017年 / 13卷 / 08期

关键词：

Tantalum; Metal toxicity; Nanoparticles; Mesenchymal stromal cells; Total hip arthroplasty; METAL-ON-METAL; WEAR PARTICLES; IMPLANTS; VITRO; CELLS; VIVO;

D O I：

10.1016/j.nano.2017.08.004

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous tantalum components are widely used for complex acetabular reconstructions in revision hip arthroplasty. Multiple other metal alloys such as titanium-aluminum-vanadium or cobalt-chromium-molybdenum are principally used in artificial joint setups. We report a case of tantalum component failure being both cause and effect of a multiple metal exposure. Our aims were to assess and to characterize associated particle exposure and biological consequences. Metal level quantification revealed substantial in vivo exposure to particulate and dissociated tantalum, zirconium, chromium, cobalt, molybdenum, titanium, aluminum and vanadium in periprosthetic compartments. Aside from micron-sized particles, nanoparticles of a broad size range and elemental composition were obtained. Histological exams verified a spectrum of necrotic changes in the periprosthetic tissues. In the presented case tantalum release was accompanied by concomitance of particles originating from other utilized metals. We conclude that an overall in vivo exposure assessment is mandatory for realistic appraisal of metal toxicity and associated risks. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：2415 / 2423

页数：9