Synthesis of 3-Aminopyrido[2,1-a]isoquinolin-4-one Derivatives via Condensation of Azlactones with 1-Alkyl-3,4-dihydroisoquinolines

被引：4

作者：

Shuvalov, Vladislav Yu ^{[1
]}

Samsonenko, Anna L. ^{[2
]}

Rozhkova, Yuliya S. ^{[3
]}

Morozov, Vyacheslav V. ^{[3
]}

Shklyaev, Yurii, V ^{[3
]}

Fisyuk, Alexander S. ^{[2
]}

机构：

[1] Omsk State Tech Univ, Lab New Organ Mat, 11 Mira Ave, Omsk 644050, Russia

[2] Omsk FM Dostoevsky State Univ, Dept Dept Organ Chem, 55a Mira Ave, Omsk 644077, Russia

[3] Inst Tech Chem UB RAS, 3 Akad Korolyeva St, Perm 614013, Russia

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 41期

基金：

俄罗斯科学基金会;

关键词：

3-aminopyridin-2(1H)-one; azlactone; nitrogen heterocycles; pyrido[2; 1-a]isoquinoline; tautomerism; ALPHA-GLUCOSIDASE INHIBITORS; ISOQUINOLINE ALKALOIDS; ASYMMETRIC-SYNTHESIS; AZA-ANNULATION; GROB REACTION; ONE-STEP; REACTIVITY; ENAMINONES; BERBERINE; DESIGN;

D O I：

10.1002/slct.202103028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactions of available 1-alkyl-3,4-dihydroisoquinolines with 4-(2,2,2-trifluoroacetyl)-, 4-acetyl- or 4-(ethoxy-methylene)-2-aryloxazol-5(4H)-ones were studied. A series of new 3-amino-6,7-dihydro-4H-pyrido[2,1-a]isoquinolin-4-one derivatives was synthesized. The intermediates formed as a result of the addition of azlactone to 1-methyl-3,4-dihydroisoquinoline were isolated. The effect of the nature of the substituents, as well as the reaction conditions on the yield and structure of the title products was revealed.

引用

页码：11265 / 11269

页数：5

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