SYNTHESIS OF UNSYMMETRICAL, gem-DISUBSTITUTED BISAMIDES

被引：6

作者：

Schafer, Gabriel ^{[1
]}

Len, Lukas ^{[1
]}

Bode, Jeffrey W. ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

HETEROCYCLES | 2015年 / 90卷 / 02期

关键词：

Bisamide; Grignard Reagent; Isocyanate; Lossen Rearrangement; AMIDES;

D O I：

10.3987/COM-14-S(K)89

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of Grignard reagents to isocyanates allowed for the first successful synthesis of ketone-derived unsymmetrical, gem-disubstituted bisamides. The key to success was the in situ generation of the isocyanates under mild reaction conditions via Lossen rearrangement from the corresponding hydroxamic acids.

引用

页码：1375 / 1386

页数：12

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