Stayin? alive: BCL-2 proteins in the hematopoietic system

被引：7
|
作者：
Zehnle, Patricia M. A. [1 ,2 ]
Wu, Ying [1 ,4 ]
Pommerening, Henrike [1 ]
Erlacher, Miriam [1 ,3 ]
机构：
[1] Univ Med Ctr Freiburg, Dept Pediat & Adolescent Med, Div Pediat Hematol & Oncol, Freiburg, Germany
[2] Univ Med Ctr Freiburg, Dept Pediat & Adolescent Med, Div Gen Pediat, Freiburg, Germany
[3] Univ Med Ctr Freiburg, Dept Pediat & Adolescent Med, Div Pediat Hematol & Oncol ogy, Mathildenstr 1, D-79106 Freiburg, Germany
[4] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Biliary Pancreat Surg, Shanghai, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY | 2022年 / 110卷
基金：
欧洲研究理事会;
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; ANTI-APOPTOTIC MCL-1; STEM-CELLS; X-L; IN-VIVO; BH3-ONLY PROTEIN; FAMILY PROTEINS; SELF-RENEWAL; SURVIVAL; EXPRESSION;
D O I：
10.1016/j.exphem.2022.03.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BH3 mimetics constitute a novel concept of antitumor therapy, inducing apoptosis via inhibition of pro -survival BCL-2 proteins. Programmed cell death is fundamental for physiological hematopoiesis; hence hematological side effects of these compounds are conceivable. Navitoclax and venetoclax have been studied extensively in the clinical setting; our knowledge of the more recently developed BCL-2 protein inhibitors specifically targeting MCL-1 or BCL-XL, however, is restricted mainly to preclinical experiments. To delineate possible adverse effects of novel BH3 mimetics on the human hematopoietic system, this review summarizes current knowledge of the function of specific antiapoptotic BCL-2 proteins in physiological hematopoiesis. (c) 2022 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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页码：1 / 12
页数：12
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