Synthesis of (E, E)-Dienones and (E, E)-Dienals via Palladium-Catalyzed γ,δ-Dehydrogenation of Enones and Enals

被引：10

作者：

Pan, Gao-Fei ^{[1
]}

Zhang, Xing-Long ^{[1
]}

Zhu, Xue-Qing ^{[1
]}

Guo, Rui-Li ^{[1
]}

Wang, Yong-Qiang ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China

来源：

ISCIENCE | 2019年 / 20卷

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; DIRECT BETA-ARYLATION; DIELS-ALDER REACTIONS; AEROBIC ALPHA; BETA-DEHYDROGENATION; 1,4-CONJUGATE ADDITION; CONJUGATED DIENONES; ALDEHYDES; KETONES; DEHYDROGENATION; ISOMERIZATION;

D O I：

10.1016/j.isci.2019.09.027

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new strategy for the synthesis of conjugated (E,E)-dienones and (E, E)-dienals via a palladium-catalyzed aerobic gamma,delta-dehydrogenation of enones and enals has been developed. The method can be employed in the direct and efficient synthesis of various (E,E)-dienones and (E,E)-dienals, including non-substituted alpha-, beta-, and gamma- and/or delta-substituted (E,E)-dienones and (E,E)-dienals. The protocol is featured by the ready accessibility and elaboration of the starting materials, good functional group compatibility, and mild reaction conditions. Furthermore, the reaction is of complete E,E-stereoselectivity and uses molecular oxygen as the sole clean oxidant.

引用

页码：229 / +

页数：90

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