Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM)

被引：42
|
作者：
Nasreen, Najmunnisa [1 ]
Mohammed, Kamal A. [1 ]
Lai, Yimu [1 ]
Antony, Veena B. [1 ]
机构：
[1] Univ Florida, Dept Med, Div Pulm & Crit Care Med, Gainesville, FL 32611 USA
来源：
CANCER LETTERS | 2007年 / 258卷 / 02期
关键词：
EphA2; EphrinA1; malignant mesothelioma; receptor tyrosine kinase; proliferation; ERK1/2;
D O I：
10.1016/j.canlet.2007.09.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of this study was to understand the possible mechanisms of activation of receptor EphA2 by its ligand ephrinA1 in malignant mesothelioma cell (MMC) growth. Activation of receptor EphA2 by its ligand ephrinA1 triggered the phosphorylation of EphA2. Ligand activation of EphA2 also induced phosphorylation of ERK1/2 and significantly decreased MMC proliferation. Ligand activated and ephrinA1 vector (pcDNA/EFNA1) transfected MMC demonstrated decreased clonal growth in 3-D matrigels when compared to resting MMC. These studies suggest that EphA2 activation by its ligand ephrinA1 transmits intracellular signals from cell membrane to nucleus via ERK1/2 signaling cascade and inhibits MM growth. Published by Elsevier Ireland Ltd.
引用
收藏
页码：215 / 222
页数：8
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