QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

被引：4

作者：

Piccininni, Jenna A. ^{[1
]}

Killinger, James S. ^{[2
,4
,6
]}

Hammad, Hoda T. ^{[3
]}

Gerber, Linda M. ^{[3
]}

Dayton, Jeffrey D. ^{[2
,5
,6
]}

机构：

[1] Columbia Univ, Med Ctr, Morgan Stanley Childrens Hosp New York, Div Pediat Cardiol,NewYork Presbyterian, 3959 Broadway, New York, NY 10032 USA

[2] Weill Cornell Med, Dept Pediat, New York, NY USA

[3] Weill Cornell Med, Dept Healthcare Policy & Res, Div Biostat & Epidemiol, New York, NY USA

[4] Weill Cornell Med, Div Pediat Crit Care, New York, NY USA

[5] Weill Cornell Med, Div Pediat Cardiol, New York, NY USA

[6] Mem Sloan Kettering Canc Ctr, Dept Pediat, 1275 York Ave, New York, NY 10021 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 02期

关键词：

QTc prolongation; ventricular arrhythmia; torsades des pointes; pediatric oncology; CHILDREN;

D O I：

10.1097/MPH.0000000000001444

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.

引用

页码：E121 / E124

页数：4

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