A COST-EFFECTIVE PAPER-BASED SERS DEVICE FOR THE DETECTION OF CORTISOL IN SALIVA

被引：0
|
作者：
Agarwal, Dilip Kumar [1 ]
Xia, Junfei [1 ]
Sadeqi, Aydin [1 ]
Owyeung, Rachel [1 ,2 ]
Nejad, Hojatollah R. [1 ]
Sonkusale, Sameer [1 ,2 ,3 ]
机构：
[1] Tufts Univ, Dept Elect & Comp Engn, Boston, MA 02111 USA
[2] Tufts Univ, Dept Chem & Biol Engn, Boston, MA 02111 USA
[3] Tufts Univ, Dept Biomed Engn, Boston, MA 02111 USA
来源：
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS) | 2021年
基金：
美国国家科学基金会;
关键词：
Surface Enhanced Raman Spectroscopy; Gold Nanoparticles; Lateral Flow SERS; Detection; Cortisol; Saliva; Paper; ELECTROCHEMICAL DETECTION;
D O I：
10.1109/TRANSDUCERS50396.2021.9495649
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Cortisol levels in saliva is an important biomarker of stress and its rapid detection is a significant need for overall management of health and wellness. Herein, we demonstrate two novel SERS-based approaches for the detection of cortisol directly in saliva using regular and novel hexagonal gold nanoparticles (AuNPs) on a paper substrate. Using the direct SERS method, we first show the detection of cortisol by mixing the cortisol solution with highly concentrated AuNPs on a Parchment paper surface as an active SERS substrate. We also propose an alternate lateral flow SERS (LFS) approach, which employs paper as a chromatographic channel to reduce interference from background saliva matrix for the detection using SERS. A rapid detection of spiked cortisol in saliva down to 100 ig/ml concentration by employing the 'lateral flow SERS' (LFS) platform is shown. Results indicate a promising route for point-of-care detection of stress biomarkers.
引用
收藏
页码：719 / 722
页数：4
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