Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla

被引：60
|
作者：
Wang, Kou [2 ,3 ]
Zhou, Xiao-Yu [1 ]
Wang, Yuan-Yuan [2 ]
Li, Ming-Ming [2 ,3 ]
Li, Yin-Shan [4 ]
Peng, Li-Yan [2 ]
Cheng, Xiao [2 ]
Li, Yan [2 ]
Wang, Yi-Ping [1 ]
Zhao, Qin-Shi [2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[4] Dali Univ, Coll Pharm, Dali 671002, Yunnan, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 01期
基金：
中国国家自然科学基金;
关键词：
INDOLE ALKALOIDS; ISORHYNCHOPHYLLINE; RHYNCHOPHYLLINE; PROLIFERATION; HOOKS; C-13;
D O I：
10.1021/np1004938
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC50 values of 13.96 and 23.28 mu M, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC50 = 6.73 mu g/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KO-induced contraction.
引用
收藏
页码：12 / 15
页数：4
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