Synthesis, crystal structure and urease inhibition of a trinuclear copper(II) complex with reduced Schiff base ligand

被引：20

作者：

Duan, Mengmeng ^{[1
]}

Li, Yanmin ^{[1
]}

Xu, Luyao ^{[1
]}

Yang, Huailan ^{[1
]}

Luo, Fuwen ^{[1
]}

Guan, Yixing ^{[1
]}

Zhang, Bitong ^{[1
]}

Jing, Changling ^{[1
]}

You, Zhonglu ^{[1
]}

机构：

[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2019年 / 100卷

关键词：

Reduced Schiff base; Copper(II) complex; Crystal structure; Urease inhibitor; HELICOBACTER-PYLORI UREASE; JACK BEAN UREASE; BIOLOGICAL EVALUATION; DERIVATIVES;

D O I：

10.1016/j.inoche.2018.12.009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A trinuclear copper(II) complex, [Cu3L2]center dot 2ClO(4)center dot 2CH(3)CN, with the reduced Schiff base ligand 2,2'-((propane-1,3-diylbis(azanediyl))bis(methylene))diphenol (H2L) was prepared. The complex was characterized by elemental analysis, IR and UV-Vis spectra, and single crystal X-ray diffraction. The ligand coordinates to the Cu atoms through the amino nitrogen and phenolate oxygen, giving square planar geometry. The ligand and the complex were tested for their Jack bean urease inhibitory activities. The IC50 value of the complex on the urease inhibition is 1.6 +/- 1.2 mu mol.L-1. Molecular docking study of the complex was performed to study the inhibition.

引用

页码：27 / 31

页数：5

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