Improvement in quality of oocytes in polycystic ovarian syndrome in programs of in vitro fertilization

被引：16
|
作者：
Vartanyan, E. V. [1 ,2 ]
Tsaturova, K. A. [1 ]
Devyatova, E. A. [1 ]
Mikhaylyukova, A. S. [1 ]
Levin, V. A. [1 ]
Petuhova, N. L. [1 ]
Markin, A. V. [1 ]
Steptsova, E. M. [1 ]
机构：
[1] Clin Assisted Reprod Technol Test Tube Babies LLC, Shchukinskaya St 2, Moscow 123182, Russia
[2] Peoples Friendship Univ Russia, Dept Obstet Gynecol & Reprod Med, Moscow, Russia
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 2017年 / 33卷
关键词：
PCOS; infertility; inositol; myo-inositol; IVF; pregnancy; INSULIN-SECRETION; MYOINOSITOL; CONSENSUS; WOMEN; PCOS;
D O I：
10.1080/09513590.2017.1399699
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inositol therapy is aimed at improving the quality of oocytes during preconception care in patients with polycystic ovarian syndrome (PCOS), a cause of infertility and reproductive dysfunction. The objectives of this observational comparative multicentre study were to evaluate the effectiveness of inositol in improving the quality of oocytes/embryos and IVF cycle outcome. Group 1 patients (N = 133) received inositol 1000mg (Inofert or Nutrilinea) +folic acid 0.1mg. Group 2 consisted of patients with preserved ovarian reserve without PCOS (N = 137), not administered inositol prior to pregnancy. Effectiveness criteria were numbers of mature oocytes and good quality embryos, pregnancy rates per ET, 'take home baby' index and miscarriage rates. Pregnancy rates per ET (87.0% vs. 87.4%), 'take home baby' index (79.6% vs. 89.4%) and miscarriage rates (14.3% vs. 10.6%) were comparable. Use of inositol in patients with PCOS during preconception care is an effective method allowing improvement of oocytes quality and positively affecting IVF cycle prognosis. High pregnancy rates per ET and ` take home baby' index after treatment are justifying inositol usage in patients with PCOS and infertility.
引用
收藏
页码：8 / 11
页数：4
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