Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging

被引：38

作者：

Dong, Ruijiao ^{[1
,2
]}

Ravinathan, Screenath P. ^{[3
]}

Xue, Lizhe ^{[4
]}

Li, Nan ^{[1
]}

Zhang, Yingjian ^{[1
]}

Zhou, Linzhu ^{[2
]}

Cao, Chengxi ^{[5
]}

Zhu, Xinyuan ^{[2
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Nucl Med,Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[2] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[3] Mahatma Gandhi Univ, Sch Chem Sci, Ctr Nanosci & Nanotechnol, Priyadarshini Hills PO, Kottayam 686560, Kerala, India

[4] Fudan Univ, Zhongshan Hosp, Dept Nucl Med, Shanghai 200032, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 51期

基金：

中国国家自然科学基金;

关键词：

HOST-GUEST INTERACTIONS; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; POLYMERS; CHEMISTRY; STIMULI; SYSTEMS; FLUORESCENCE; DNA;

D O I：

10.1039/c6cc02794f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dual-responsive aggregation-induced emission-active supramolecular fluorescent nanoparticles are reported, which have the ability to undergo a unique morphological transition combining with a cooperative optical variation in response to pH and light stimuli. The dynamic supramolecular nanoparticles show excellent biocompatibility and effective plasmid DNA condensation capability, further achieving efficient in vitro gene delivery and bioimaging.

引用

页码：7950 / 7953

页数：4

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