The effects of cocaine on nonhuman primate brain function are age dependent

被引：10

作者：

Paule, MG ^{[1
]}

Gillam, MP ^{[1
]}

Morris, P ^{[1
]}

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Behav Toxicol Lab, Jefferson, AR 72079 USA

来源：

NEUROCHEMISTRY OF DRUGS OF ABUSE: COCAINE, IBOGAINE, AND SUBSTITUTED AMPHETAMINES | 1998年 / 844卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb08232.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effects of acute intravenous (i.v.) cocaine (COC) on several complex brain functions were studied in rhesus monkeys at 1.5, 3 anti 10-11 pars of age. Subjects performed several operant tasks (for food) that were used to model learning, short-term memory, color and position discrimination, and motivation, and disruption of performance of these tasks was used to quantitate drug effect. Drug effects were age dependent: The youngest subjects were 3 to 10 times less sensitive than the oldest. Presuming the observed behavioral effects of cocaine were caused primarily via its interaction with dopamine (DA) systems, changes in sensitivity to its effects with age are likely a reflection of the functional status of the DA system. These data, along with preliminary data on levels of DA transporters, suggest that the age-related differences in sensitivity to cocaine lie iu, or 'downstream' from, the dopamine receptor.

引用

页码：178 / 182

页数：5