5-HT2A receptor antagonist M100907 reduces serotonin synthesis: An autoradiographic study

被引：3
|
作者：
Hasegawa, Shu [1 ,2 ]
Fikre-Merid, Maraki [1 ]
Diksic, Mirko [1 ]
机构：
[1] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Cone Neurosurg Res Lab, Montreal, PQ H3A 2B4, Canada
[2] Kumamoto Univ, Sch Med, Dept Neurosurg, Kumamoto 860, Japan
来源：
BRAIN RESEARCH BULLETIN | 2012年 / 87卷 / 01期
关键词：
alpha-[C-14]methyl-L-tryptophan; Serotonin synthesis rate; 5-HT2A receptor antagonist; M100907; Autoradiography; ATYPICAL ANTIPSYCHOTIC-DRUGS; RAT-BRAIN; TRYPTOPHAN-HYDROXYLASE; ULTRASTRUCTURAL-LOCALIZATION; REUPTAKE INHIBITORS; CHRONIC FLUOXETINE; PREFRONTAL CORTEX; DOPAMINE RELEASE; SYNTHESIS INVIVO; MDL 100,907;
D O I：
10.1016/j.brainresbull.2011.10.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of the administration of the serotonin (5-HT)(2A) antagonist, M100907, on 5-HT synthesis rates, were evaluated using the alpha-[C-14]methyl-L-tryptophan (alpha-MTrp) autoradiographic method. In the treatment study, M100907 (10 mg/kg) was injected intraperitoneally 30 min before the alpha-MTrp injection (30 mu Ci over 2 min). A single dose of M100907 caused a significant decrease in the synthesis in the anterior olfactory nucleus, accumbens nucleus, frontal cortex, sensory-motor cortex, cingulate cortex, medial caudate-putamen, dorsal thalamus, substantia nigra, inferior collicus, raphe magnus nucleus, superior olive, and raphe pallidus nucleus. These data suggest that the terminal 5-HT2A receptors are involved in the regulation of 5-HT synthesis in the entire brain. Further, 5-HT synthesis is likely regulated by the 5-HT2A antagonistic property of M100907 in the cortices, anterior olfactory nucleus, caudate putamen, and nucleus accumbens. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：44 / 49
页数：6
相关论文
共 50 条
  • [1] Actions of the 5-HT2A antagonist M100907 in serotonin-depleted mice
    Fantegrossi, WE
    Kilbourn, M
    Woods, JH
    FASEB JOURNAL, 2004, 18 (05): : A965 - A965
  • [2] Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907
    Gilbertson, Scott R.
    Chen, Ying-Chu
    Soto, Claudia A.
    Yang, Yaxing
    Rice, Kenner C.
    Cunningham, Kathryn A.
    Anastasio, Noelle C.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (08) : 1381 - 1385
  • [3] The 5-HT2A receptor antagonist M100907 produces antiparkinsonian effects and decreases striatal glutamate
    Ansah, Twum A.
    Ferguson, Marcus C.
    Nayyar, Tultul
    FRONTIERS IN SYSTEMS NEUROSCIENCE, 2011, 5
  • [4] The Serotonin 5-HT2A Receptors Antagonist M100907 Prevents Impairment in Attentional Performance by NMDA Receptor Blockade in the Rat Prefrontal Cortex
    Carli Mirjana
    Marta Baviera
    Roberto W Invernizzi
    Claudia Balducci
    Neuropsychopharmacology, 2004, 29 : 1637 - 1647
  • [5] The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex
    Mirjana, C
    Baviera, M
    Invernizzi, RW
    Balducci, C
    NEUROPSYCHOPHARMACOLOGY, 2004, 29 (09) : 1637 - 1647
  • [6] Autoradiographic localization of 5-HT2A receptors in the human brain using L3H]M100907 and [11C]M100907
    Hall, H
    Farde, L
    Halldin, C
    Lundkvist, C
    Sedvall, G
    SYNAPSE, 2000, 38 (04) : 421 - 431
  • [7] The apparent antipsychotic action of the 5-HT2a receptor antagonist M100907 in a mouse model of schizophrenia is counteracted by ritanserin
    P. Martin
    N. Waters
    A. Carlsson
    M. L. Carlsson
    Journal of Neural Transmission, 1997, 104 : 561 - 564
  • [8] Erratum: The Serotonin 5-HT2A Receptors Antagonist M100907 Prevents Impairment in Attentional Performance by NMDA Receptor Blockade in the Rat Prefrontal Cortex
    Mirjana Carli
    Marta Baviera
    Roberto W Invernizzi
    Claudia Balducci
    Neuropsychopharmacology, 2004, 29 : 2300 - 2300
  • [9] The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist than dopamine agonist induced hyperactivity in mice
    Carlsson, ML
    Martin, P
    Nilsson, M
    Sorensen, SM
    Carlsson, A
    Waters, S
    Waters, N
    JOURNAL OF NEURAL TRANSMISSION, 1999, 106 (02) : 123 - 129
  • [10] Clinical and pet effects of M100907, a selective 5HT-2A receptor antagonist
    Potkin, SG
    Shipley, J
    Bera, RB
    Carreon, D
    Fallon, J
    Alva, G
    Keator, D
    SCHIZOPHRENIA RESEARCH, 2001, 49 (1-2) : 242 - 242
12345