N-terminal processing:: the methionine aminopeptidase and Nα-acetyl transferase families

被引：406
|
作者：
Bradshaw, RA [1 ]
Brickey, WW
Walker, KW
机构：
[1] Univ Calif Irvine, Coll Med, Dept Physiol & Biophys, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Coll Med, Dept Neurobiol & Anat, Irvine, CA 92697 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 07期
关键词：
D O I：
10.1016/S0968-0004(98)01227-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N-alpha-acetyltransferase respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellullar location, function, and evolutionary origins.
引用
收藏
页码：263 / 267
页数：5
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