Modification of chitosan membrane with poly(vinyl alcohol) and biocompatibility evaluation

被引：76
|
作者：
Zhuang, Peng-Yu [1 ]
Li, You-Liang [1 ]
Fan, Li [2 ]
Lin, Jun [2 ]
Hu, Qiao-Ling [1 ]
机构：
[1] Zhejiang Univ, Key Lab Macromole Synth & Functionalizat, Dept Polymer Sci & Engn, Inst Biomed Macromol,Minist Educ, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 50卷 / 03期
基金：
美国国家科学基金会;
关键词：
Chitosan; Poly(vinyl alcohol); Biocompatibility; SURFACE MODIFICATION; BONE REGENERATION; SCAFFOLDS; BLENDS; FABRICATION; COMPATIBILITY;
D O I：
10.1016/j.ijbiomac.2012.01.026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This work aimed to overcome chitosan (CS) membrane' drawbacks: mainly stiffness and hydrophobic surface by adding poly(vinyl alcohol) (PVA) and evaluate their biocompatibility. The chemical structure, crystalline and thermal properties were studied by FT-IR, XRD and DSC. The mechanical properties and wettability of CS/PVA membranes were studied by tensile test and static contact angle measurement. In vitro biocompatibility was also evaluated by MTS cytotoxicity assay and SEM examination. The results suggest that adding PVA into CS membrane could greatly improve CS membrane's flexibility and wettability. All the membranes prepared were biocompatible and have potential applications in GTR technology. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：658 / 663
页数：6
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