Molecular profiling of common fragile sites in human fibroblasts

被引：99

作者：

Le Tallec, Benoit ^{[2
,3
,4
]}

Dutrillaux, Bernard ^{[1
]}

Lachages, Anne-Marie ^{[2
,3
,4
]}

Millot, Gael Armel ^{[2
,3
,4
]}

Brison, Olivier ^{[2
,3
,4
]}

Debatisse, Michelle ^{[2
,3
,4
]}

机构：

[1] Museum Natl Hist Nat, CNRS, UMR 7205, F-75231 Paris, France

[2] Ctr Rech, Inst Curie, Paris, France

[3] Univ Paris 06, Paris, France

[4] CNRS, UMR 3244, Paris, France

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2011年 / 18卷 / 12期

关键词：

REPLICATION STRESS; CANCER; GENES; CHROMOSOMES; MITOSIS;

D O I：

10.1038/nsmb.2155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type-dependent replication programs. Using a new approach, we molecularly mapped common fragile sites in human fibroblasts and showed that commitment to fragility depends on similar replication features in fibroblasts and lymphocytes, although different loci are committed in each cell type. Notably, the common fragile sites that we identified overlapped heretofore unexplained deletion clusters observed in tumors.

引用

页码：1421 / 1423

页数：3

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