Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio-communicative profiles in infants at high and low risk for autism

被引:12
|
作者
Okada, Nana J. [1 ]
Liu, Janelle [1 ]
Tsang, Tawny [1 ]
Nosco, Erin [1 ,2 ]
McDonald, Nicole M. [1 ,2 ]
Cummings, Kaitlin K. [1 ]
Jung, Jiwon [1 ]
Patterson, Genevieve [1 ]
Bookheimer, Susan Y. [1 ,2 ]
Green, Shulamite A. [1 ,2 ]
Jeste, Shafali S. [3 ]
Dapretto, Mirella [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA
[3] Childrens Hosp Los Angeles, USC Keck Sch Med, Los Angeles, CA 90027 USA
关键词
Autism spectrum disorder; infancy; fMRI; social communication; WORKING-MEMORY; PREFRONTAL CORTEX; BASAL GANGLIA; GRAY-MATTER; EARLY BRAIN; LANGUAGE; CHILDREN; SIBLINGS; NETWORK; PROJECTIONS;
D O I
10.1111/jcpp.13555
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Background While the cerebellum is traditionally known for its role in sensorimotor control, emerging research shows that particular subregions, such as right Crus I (RCrusI), support language and social processing. Indeed, cerebellar atypicalities are commonly reported in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by socio-communicative impairments. However, the cerebellum's contribution to early socio-communicative development remains virtually unknown. Methods Here, we characterized functional connectivity within cerebro-cerebellar networks implicated in language/social functions in 9-month-old infants who exhibit distinct 3-year socio-communicative developmental profiles. We employed a data-driven clustering approach to stratify our sample of infants at high (n = 82) and low (n = 37) familial risk for ASD into three cohorts-Delayed, Late-Blooming, and Typical-who showed unique socio-communicative trajectories. We then compared the cohorts on indices of language and social development. Seed-based functional connectivity analyses with RCrusI were conducted on infants with fMRI data (n = 66). Cohorts were compared on connectivity estimates from a-priori regions, selected on the basis of reported coactivation with RCrusI during language/social tasks. Results The three trajectory-based cohorts broadly differed in social communication development, as evidenced by robust differences on numerous indices of language and social skills. Importantly, at 9 months, the cohorts showed striking differences in cerebro-cerebellar circuits implicated in language/social functions. For all regions examined, the Delayed cohort exhibited significantly weaker RCrusI connectivity compared to both the Late-Blooming and Typical cohorts, with no significant differences between the latter cohorts. Conclusions We show that hypoconnectivity within distinct cerebro-cerebellar networks in infancy predicts altered socio-communicative development before delays overtly manifest, which may be relevant for early detection and intervention. As the cerebellum is implicated in prediction, our findings point to probabilistic learning as a potential intermediary mechanism that may be disrupted in infancy, cascading into alterations in social communication.
引用
收藏
页码:1002 / 1016
页数:15
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