Arterial Stiffness, Cognitive Dysfunction and Adherence to Antihypertensive Agents. Is there a Link to Hypertensive Patients?

被引:6
|
作者
Kalaitzidis, Rigas G. [1 ]
Panagiotopoulou, Thalia [2 ]
Stagikas, Dimitrios [2 ]
Pappas, Kosmas [2 ]
Balafa, Olga [1 ]
Elisaf, Moses S. [2 ]
机构
[1] Univ Hosp Ioannina, Hypertens Excellence Ctr, Div Nephrol, Ioannina, Greece
[2] Univ Ioannina, Med Sch, Dept Internal Med, Ioannina 45110, Greece
关键词
Hypertension; arterial stiffness; cognitive dysfunction; adherence to medication; cardiovascular disease; arterial pressure; BLOOD-PRESSURE CONTROL; MEDICATION ADHERENCE; RISK-FACTORS; PSYCHOMETRIC PROPERTIES; CHINESE VERSION; DRUG ADHERENCE; HEART-FAILURE; THERAPY; HEALTH; SCALE;
D O I
10.2174/1570161117666190415112953
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The incidence of hypertension (HTN) and its cardiovascular (CV) complications are increasing throughout the world. Blood pressure (BP) control remains unsatisfactory worldwide. Medical inertia and poor adherence to treatment are among the factors that can partially explain, why BP control rate remains low. The introduction of a method for measuring the degree of adherence to a given medication is now a prerequisite. Complex treatment regimes, inadequate tolerance and frequent replacements of pharmaceutical formulations are the most common causes of poor adherence. In contrast, the use of stable combinations of antihypertensive drugs leads to improved patient adherence. We aim to review the relationships between arterial stiffness, cognitive function and adherence to medication in patients with HTN. Large artery stiffening can lead to HTN. In turn, arterial stiffness induced by HTN is associated with an increased CV and stroke risk. In addition, HTN can induce disorders of brain microcirculation resulting in cognitive dysfunction. Interestingly, memory cognitive dysfunction leads to a reduced adherence to drug treatment. Compliance with antihypertensive treatment improves BP control and arterial stiffness indices. Early treatment of arterial stiffness is strongly recommended for enhanced cognitive function and increased adherence.
引用
收藏
页码:410 / 417
页数:8
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