Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

Background Previous studies have investigated the close association between the MTHFR C677T polymorphism and the risk of coronary heart disease (CAD) in the Chinese population. However, the results remain inconclusive. Therefore, this meta-analysis was performed to derive a more precise estimate of these associations. Methods Odds ratios (OR) with 95% confidence intervals (CI) were used to assess the relationship between the MTHFR C677T polymorphism and the risk of CAD. Studies were identified by searching the literature for articles published before 2017. Results A total of 39 studies comprising 12,101 individuals (6117 cases and 5984 controls) were included. For the allelic model T vs. C, the pooled OR was 1.43 (95% CI: 1.30-1.57, p < 0.0001); for the recessive model TT vs. CC + TC, the pooled OR was 1.48 (95% CI: 1.29-1.70, p < 0.0001); for the dominant model TT + TC vs. CC, the pooled OR was 1.65 (95% CI: 1.43-1.89, p < 0.0001). Conclusion In the subgroup analysis of high-quality studies, an obvious association was observed between the MTHFR C677T polymorphism and CAD risk in the Chinese population.