Anticancer Activity of the Bioreductive and Non-Bioreductive Zerumbone Derivatives

被引：11
|
作者：
Pitchuanchom, Siripit [1 ,2 ]
Songsiang, Uraiwan [1 ,2 ]
Weerapreeyakul, Natthida [3 ]
Yenjai, Chavi [1 ,2 ]
机构：
[1] Khon Kaen Univ, Dept Chem, Nat Prod Res Unit, Khon Kaen 40002, Thailand
[2] Khon Kaen Univ, Fac Sci, Ctr Innovat Chem, Khon Kaen 40002, Thailand
[3] Khon Kaen Univ, Fac Pharmaceut Sci, Ctr Res & Dev Herbal Hlth Prod, Khon Kaen 40002, Thailand
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 06期
关键词：
Bioreductive; KB; NCI-H187; MCF-7; Zerumbone derivatives; Zingiber zerumbet Smith; SESQUITERPENE; CELLS; ACTIVATION; APOPTOSIS; ESTERS;
D O I：
10.2174/157018011795906811
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Zerumbonoquinone 10 and zerumbonaminone 11 have been designed to release toxic moieties selectively and preferentially under reductive conditions. These compounds were synthesized by coupling the quinone delivery system with zerumbone alcohol 8 and amine 9. All compounds were evaluated for cytotoxicity against KB (non reductase over-expressing cells), NCI-H187 and MCF-7 (reductase overexpressing cells) and normal cells (Vero cells). Bioreductive compounds 10 and 11 were found to act as bioreductive anticancer agents exhibiting less cytotoxicity than the parents 8 and 9 in KB cells with good stability, and were partially bioreductively active against MCF-7 and NCI-H187 cells.
引用
收藏
页码：536 / 543
页数：8
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