CRISPR-Powered Microfluidics in Diagnostics: A Review of Main Applications

被引：13
|
作者：
Azimzadeh, Mostafa [1 ,2 ,3 ]
Mousazadeh, Marziyeh [4 ]
Jahangiri-Manesh, Atieh [4 ]
Khashayar, Pouria [5 ]
Khashayar, Patricia [6 ,7 ]
机构：
[1] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Biotechnol, Yazd 89165887, Iran
[2] Shahid Sadoughi Univ Med Sci, Yazd Reprod Sci Inst, Med Nanotechnol & Tissue Engn Res Ctr, Yazd 89195999, Iran
[3] Shahid Sadoughi Univ Med Sci, Yazd Reprod Sci Inst, Stem Cell Biol Res Ctr, Yazd 89195999, Iran
[4] Tarbiat Modares Univ, Fac Biol Sci, Dept Nanobiotechnol, Tehran 14115111, Iran
[5] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland
[6] Imec, Ctr Microsyst Technol, B-9050 Ghent, Belgium
[7] Univ Ghent, B-9050 Ghent, Belgium
来源：
CHEMOSENSORS | 2022年 / 10卷 / 01期
关键词：
microfluidics; lab-on-chip; CRISPR; biosensor; medical detection; NUCLEIC-ACID DETECTION; ASSAY; DELIVERY; CAS12A; FUTURE;
D O I：
10.3390/chemosensors10010003
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In the past few years, the CRISPR (clustered regularly interspaced short palindromic repeats) applications in medicine and molecular biology have broadened. CRISPR has also been integrated with microfluidic-based biosensors to enhance the sensitivity and selectivity of medical diagnosis due to its great potentials. The CRISPR-powered microfluidics can help quantify DNAs and RNAs for different diseases such as cancer, and viral or bacterial diseases among others. Here in this review, we discussed the main applications of such tools along with their advantages and limitations.
引用
收藏
页数：20
相关论文
共 50 条
  • [1] BIOSENSING CRISPR-powered diagnostics
    Zuo, Xiaolei
    Fan, Chunhai
    Chen, Hong-Yuan
    NATURE BIOMEDICAL ENGINEERING, 2017, 1 (06):
  • [2] Biosensing: CRISPR-powered diagnostics
    Xiaolei Zuo
    Chunhai Fan
    Hong-Yuan Chen
    Nature Biomedical Engineering, 1
  • [3] CRISPR-Powered Aptasensor for Diagnostics of Alzheimer's Disease
    Jia, Zhengyang
    Maghaydah, Yazeed
    Zdanys, Kristina
    Kuchel, George A.
    Diniz, Breno Satler
    Liu, Changchun
    ACS SENSORS, 2023, 9 (01) : 398 - 405
  • [4] CRISPR-Powered Strategies for Amplification-Free Diagnostics of Infectious Diseases
    Xia, Yupiao
    Rao, Ruotong
    Xiong, Mengqiu
    He, Bangshun
    Zheng, Bingxin
    Jia, Yanwei
    Li, Ying
    Yang, Yunhuang
    ANALYTICAL CHEMISTRY, 2024, 96 (20) : 8091 - 8108
  • [5] CRISPR-Based Diagnostics and Microfluidics for COVID-19 Point-of-Care Testing: A Review of Main Applications
    Fatemeh Nafian
    Simin Nafian
    Babak Kamali Doust Azad
    Mehrdad Hashemi
    Molecular Biotechnology, 2023, 65 : 497 - 508
  • [6] CRISPR-Based Diagnostics and Microfluidics for COVID-19 Point-of-Care Testing: A Review of Main Applications
    Nafian, Fatemeh
    Nafian, Simin
    Kamali Doust Azad, Babak
    Hashemi, Mehrdad
    MOLECULAR BIOTECHNOLOGY, 2023, 65 (04) : 497 - 508
  • [7] CRISPR-Powered DNA Computing and Digital Display
    Zhang, Jiongyu
    Liu, Changchun
    ACS SYNTHETIC BIOLOGY, 2021, 10 (11): : 3148 - 3157
  • [8] CRISPR-powered electrochemical microfluidic multiplexed biosensor for target amplification-free miRNA diagnostics
    Bruch, Richard
    Johnston, Midori
    Kling, Andre
    Mattmueller, Thorsten
    Baaske, Julia
    Partel, Stefan
    Madlener, Sibylle
    Weber, Wilfried
    Urban, Gerald A.
    Dincer, Can
    BIOSENSORS & BIOELECTRONICS, 2021, 177
  • [9] CRISPR-Powered Strategies for Amplification-Free Diagnostics of Infectious Diseases (vol 96, pg 8091, 2024)
    Xia, Yupiao
    Rao, Ruotong
    Xiong, Mengqiu
    He, Bangshun
    Zheng, Bingxin
    Jia, Yanwei
    Li, Ying
    Yang, Yunhuang
    ANALYTICAL CHEMISTRY, 2024, 96 (39) : 15824 - 15826
  • [10] CRISPR-Powered Graphene Electronics-A New Generation of Bioelectronics for CRISPR Quality Control
    Aran, Kiana
    MOLECULAR THERAPY, 2023, 31 (04) : 265 - 265
12345