Age-Dependent Changes in Na+,K+-ATPase Activity and Lipid Peroxidation in Membranes of Erythrocytes during Cardiosclerosis Development in Rats

被引：2
|
作者：
Rebrova, T. Yu. [1 ]
Afanasiev, S. A. [1 ]
Popov, S. V. [1 ]
机构：
[1] Cardiol Res Inst, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 02期
关键词：
lipid peroxidation; Na+; K+-ATPase; postinfarction cardiosclerosis; age;
D O I：
10.1007/s10517-016-3384-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Activity of Na+,K+-ATPase was measured in erythrocyte ghosts of 4- and 12-month-old rats, intact and with postinfarction cardiosclerosis. Enhanced accumulation of secondary LPO products and reduced activity of Na+,K+-ATPase were observed in erythrocyte ghosts of 12-month-old rats. The development of postinfarction cardiosclerosis in 4-month-old rats was accompanied by enhanced accumulation of LPO products and decreased activity of Na+,K+-ATPase. In comparison with young rats with postinfarction cardiosclerosis, 12-month-old rats with this pathology were characterized by less pronounced decrease in Na+,K+-ATPase activity and increase in accumulation of LPO products in comparison with intact control.
引用
收藏
页码：235 / 236
页数：2
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