Effects of telomerase and telomere length on epidermal stem cell behavior

被引：327
|
作者：
Flores, I [1 ]
Cayuela, ML [1 ]
Blasco, MA [1 ]
机构：
[1] Spanish Natl Canc Ctr, Mol Oncol Program, Telomeres & Telomerase Grp, E-28029 Madrid, Spain
来源：
SCIENCE | 2005年 / 309卷 / 5738期
关键词：
D O I：
10.1126/science.1115025
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A key process in organ homeostasis is the mobilization of stem cells out of their niches. We show through analysis of mouse models that telomere length, as well as the catalytic component of telomerase, Tert, are critical determinants in the mobilization of epidermal stem cells. Telomere shortening inhibited mobilization of stem cells out of their niche, impaired hair growth, and resulted in suppression of stem cell proliferative capacity in vitro. In contrast, Tert overexpression in the absence of changes in telomere length promoted stem cell mobilization, hair growth, and stem cell proliferation in vitro. The effects of telomeres and telomerase on stem cell biology anticipate their role in cancer and aging.
引用
收藏
页码：1253 / 1256
页数：4
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