Bioactive triterpene saponins from the roots of Phytolacca americana

被引：42

作者：

Wang, Liyan ^{[1
,2
]}

Bai, Lin-Ting ^{[1
,2
]}

Nagasawa, Takashi ^{[1
,2
]}

Hasegawa, Toshiaki ^{[1
,2
,3
]}

Yang, Xiaoyang ^{[1
,2
]}

Sakai, Jun-ichi

Bai, Yuhua ^{[1
,2
]}

Kataoka, Takao ^{[4
]}

Oka, Seiko ^{[5
]}

Hirose, Katsutoshi ^{[6
]}

Tomida, Akihiro ^{[7
]}

Tsuruo, Takashi ^{[7
]}

Ando, Masayoshi

机构：

[1] Niigata Univ, Grad Sch Sci & Technol, Nishi Ku, Niigata 9502181, Japan

[2] Niigata Univ, Dept Chem & Chem Engn, Nishi Ku, Niigata 9502181, Japan

[3] Mitsubishi Gas Chem Co Inc, Niigata Res Lab, Kita Ku, Niigata 9503112, Japan

[4] Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[5] Hokkaido Univ, Ctr Instrumental Anal, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[6] KNC Labs Co Ltd, Nishi Ku, Kobe, Hyogo 6512271, Japan

[7] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Koto Ku, Tokyo 1358500, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 01期

关键词：

D O I：

10.1021/np078012m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new triterpene saponins named phytolaccasaponins N-1 (1), N-2 (2), N-3 (3) N-4 (4), and N-5 (5) were isolated from the roots of Phytolacca americana together with seven known triterpene saponins (6-12). The structures of the five new saponins were established as shown in structures 1-5 on the basis of their spectroscopic data. The MDR-reversal activity of 1-12 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780 AD cells in the presence of each compound. The most effective compound was 8 (155% of control at 25 mu g/mL).

引用

页码：35 / 40

页数：6

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