Efficacy and safety of the cathepsin K inhibitor, ONO-5334, and alendronate on post-menopausal osteopenia or osteoporosis: 2-year results from ocean study

被引:0
|
作者
Eastell, R. [1 ]
Nagase, S. [2 ]
Boonen, S. [3 ]
Spector, T. [4 ]
Small, M. [2 ]
Kuwayama, T. [2 ]
Sawyer, J. [5 ]
Deacon, S. [2 ]
机构
[1] No Gen Hosp, Sheffield S5 7AU, S Yorkshire, England
[2] Ono Pharma UK Ltd, Clin Dev, London, England
[3] Katholieke Univ Leuven, Leuven, Belgium
[4] Kings Coll London, London WC2R 2LS, England
[5] Prism Biodev Ltd, Nantwich, Cheshire, England
关键词
D O I
10.1016/j.bone.2011.03.131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S92 / S93
页数:2
相关论文
共 50 条
  • [1] Safety and Efficacy of the Cathepsin K Inhibitor ONO-5334 in Postmenopausal Osteoporosis: The OCEAN Study
    Eastell, Richard
    Nagase, Shinichi
    Ohyama, Michiyo
    Small, Maria
    Sawyer, James
    Boonen, Steven
    Spector, Tim
    Kuwayama, Tomohiro
    Deacon, Steve
    JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (06) : 1303 - 1312
  • [2] The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study
    Engelke, Klaus
    Nagase, Shinichi
    Fuerst, Thomas
    Small, Maria
    Kuwayama, Tomohiro
    Deacon, Stephen
    Eastell, Richard
    Genant, Harry K.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (03) : 629 - 638
  • [3] Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin K inhibitor, ONO-5334, in healthy post-menopausal women
    Nagase, Shinichi
    Ohyama, Michiyo
    Hashimoto, Yoshitaka
    Small, Maria
    Sharpe, John
    Manako, Junichiro
    Kuwayama, Tomohiro
    Deacon, Steve
    JOURNAL OF BONE AND MINERAL METABOLISM, 2015, 33 (01) : 93 - 100
  • [4] Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin K inhibitor, ONO-5334, in healthy post-menopausal women
    Shinichi Nagase
    Michiyo Ohyama
    Yoshitaka Hashimoto
    Maria Small
    John Sharpe
    Junichiro Manako
    Tomohiro Kuwayama
    Steve Deacon
    Journal of Bone and Mineral Metabolism, 2015, 33 : 93 - 100
  • [5] Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study
    Eastell, Richard
    Nagase, Shinichi
    Small, Maria
    Boonen, Steven
    Spector, Tim
    Ohyama, Michiyo
    Kuwayama, Tomohiro
    Deacon, Steve
    JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (02) : 458 - 466
  • [6] Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women
    Nagase, Shinichi
    Hashimoto, Yoshitaka
    Small, Maria
    Ohyama, Michiyo
    Kuwayama, Tomohiro
    Deacon, Steve
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 74 (06) : 959 - 970
  • [7] Modeling and Simulation of Bone Mineral Density Response From a Phase 2 Study of ONO-5334, a New Cathepsin K Inhibitor, to Support Dose Selection in Osteoporosis
    Hasegawa, Chihiro
    Kastrissios, Helen
    Monteleone, Jonathan
    Ohno, Tomoya
    Umemura, Takeo
    Ohyama, Michiyo
    Nagase, Shinichi
    Small, Maria
    Deacon, Steve
    Ogawa, Mikio
    Ieiri, Ichiro
    JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 54 (08): : 937 - 948
  • [8] SAFETY, TOLERABILITY AND PHARMACOKINETICS OF THE NOVEL CATHEPSIN K INHIBITOR, ONO-5334, IN POSTMENOPAUSAL WOMEN: AN ASCENDING SINGLE AND MULTIPLE DOSE PHASE I STUDY
    Nagase, S.
    Hashimoto, Y.
    Ohyama, M.
    Kuwayama, T.
    Deacon, S.
    OSTEOPOROSIS INTERNATIONAL, 2010, 21 : 339 - 339
  • [9] Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys
    Hiroyuki Yamada
    Yasuo Ochi
    Hiroshi Mori
    Satoshi Nishikawa
    Yasuaki Hashimoto
    Makoto Tanaka
    Steve Deacon
    Kazuhito Kawabata
    Journal of Bone and Mineral Metabolism, 2019, 37 : 636 - 647
  • [10] Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys
    Yamada, Hiroyuki
    Ochi, Yasuo
    Mori, Hiroshi
    Nishikawa, Satoshi
    Hashimoto, Yasuaki
    Tanaka, Makoto
    Deacon, Steve
    Kawabata, Kazuhito
    JOURNAL OF BONE AND MINERAL METABOLISM, 2019, 37 (04) : 636 - 647