"On-water" reduction of α-keto amide by Hantzsch ester: A chemoselective catalyst- and additive-free way to α-hydroxy amide

被引：6
|
作者：
Fang, Zhong-Bing [1 ]
Yu, Ru-Rong [1 ]
Hao, Fei-Yue [1 ]
Jin, Zheng-Neng [1 ]
Liu, Gu-Yue [1 ]
Dai, Guo-Liang [2 ]
Yao, Wu-Bing [1 ]
Wu, Jia-Shou [1 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou, Zhejiang, Peoples R China
[2] Suzhou Univ Sci & Technol, Sch Chem Biol & Mat Engn, Suzhou, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 86卷
基金：
中国国家自然科学基金;
关键词：
On-water; Chemoselective reduction; alpha-Keto amide; alpha-Hydroxy amide; Hantzsch ester; TRANSFER HYDROGENATION; ENANTIOSELECTIVE HYDROGENATION; ASYMMETRIC HYDROGENATION; ACID-DERIVATIVES; EFFICIENT; ROUTE;
D O I：
10.1016/j.tetlet.2021.153524
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical method for chemoselective "on-water" reduction of alpha-keto amide by Hantzsch ester without using any catalysts and additives was developed. Control experiments indicated that the intramolecular hydrogen bond of alpha-keto amide was crucial for this transformation. A variety of alpha-hydroxy amides were prepared in high yields in an environmentally friendly way. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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