Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children

被引：25

作者：

Nsiah-Kumi, Phyllis A. ^{[1
]}

Erickson, Judi M. ^{[1
]}

Beals, Jennifer L. ^{[1
]}

Ogle, Eric A. ^{[1
]}

Whiting, Mary ^{[1
,2
]}

Brushbreaker, Connie ^{[2
]}

Borgeson, Claudia D. ^{[1
]}

Qiu, Fang ^{[1
]}

Yu, Fang ^{[1
]}

Larsen, Jennifer L. ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Omaha, NE 68198 USA

[2] Rosebud Sioux Tribe, Rosebud, SD USA

来源：

CLINICAL PEDIATRICS | 2012年 / 51卷 / 02期

关键词：

25(OH) vitamin D; 25-hydroxyvitamin D; diabetes; insulin resistance; lipids; obesity; type 2 diabetes prevention; vascular risk; D DEFICIENCY; 25-HYDROXYVITAMIN D; ADOLESCENT POPULATION; INSULIN-RESISTANCE; HYPOVITAMINOSIS-D; NATIONAL-HEALTH; OBESE CHILDREN; PREVENTION; ADIPOSITY; NUTRITION;

D O I：

10.1177/0009922811417290

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aims/Hypothesis. Vitamin D insufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance. Methods. In a cross-section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25-hydroxy-vitamin D concentration [25(OH) vitamin D] were measured. BMI% and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Results. Mean age was 10.8 +/- 0.3 years (mean +/- SEM). Mean serum 25(OH) vitamin D was 17.8 +/- 0.4 ng/mL and 97% had vitamin D insufficiency [25(OH) vitamin D < 30 ng/mL]. After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA-IR (P < .0001) and several other markers of insulin resistance. Conclusions/Interpretation. Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.

引用

页码：146 / 153

页数：8

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