Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips

被引：9
|
作者：
Na, Xiaofan [1 ]
Hu, Yanfeng [1 ]
Yue, Kun [1 ]
Lu, Hongxia [1 ]
Jia, Pengfei [1 ]
Wang, Huahua [1 ]
Wang, Xiaomin [1 ]
Bi, Yurong [1 ]
机构：
[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China
来源：
BMC PLANT BIOLOGY | 2011年 / 11卷
基金：
中国国家自然科学基金;
关键词：
KINASE INHIBITOR; PLANT DEVELOPMENT; TRANSCRIPTION FACTOR; AUXIN TRANSPORT; CDK INHIBITORS; CANCER-CELLS; PROTEIN; THALIANA; PROLIFERATION; EXPRESSION;
D O I：
10.1186/1471-2229-11-184
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Background: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. Results: Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 mu M) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 mu M) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases. Conclusions: Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings.
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页数：13
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