Simple and efficient synthesis of arbutin

被引：19

作者：

Cepanec, Ivica ^{[1
]}

Litvic, Mladen ^{[1
]}

机构：

[1] BELUPO Pharmaceut Inc, Res Dept, Koprivnica 48000, Croatia

来源：

ARKIVOC | 2008年

关键词：

arbutin; glycosides; transesterification; Lewis acids; natural products;

D O I：

10.3998/ark.5550190.0009.203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of arbutin, 4-hydroxyphenyl-D-glucopyranoside (1), in both alpha- and beta-anomeric form, starting from penta-O-acetyl-alpha(beta)-D-glucopyranoside ( 2) and 4-hydroxyphenylacetate ( 3) was developed. The BF3 center dot Et2O-catalysed glycosylation reaction of 2 with 3 proceeds with complete retention of anomeric configuration.

引用

页码：19 / 24

页数：6

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