Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation-relevance for (pre)diabetes: The Maastricht Study

被引：42

作者：

Vandercappellen, Evelien J. ^{[1
,2
,3
]}

Koster, Annemarie ^{[3
,4
]}

Savelberg, Hans H. C. M. ^{[5
,6
]}

Eussen, Simone J. P. M. ^{[2
,7
]}

Dagnelie, Pieter C. ^{[1
,2
]}

Schaper, Nicolaas C. ^{[1
,2
,3
]}

Schram, Miranda T. ^{[1
,2
,8
,9
]}

van der Kallen, Carla J. H. ^{[1
,2
]}

van Greevenbroek, Marleen M. J. ^{[1
,2
]}

Wesselius, Anke ^{[6
,10
]}

Schalkwijk, Casper G. ^{[1
,2
]}

Kroon, Abraham A. ^{[1
,2
,9
]}

Henry, Ronald M. A. ^{[1
,2
,9
]}

Stehouwer, Coen D. A. ^{[1
,2
]}

机构：

[1] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands

[2] Maastricht Univ, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands

[3] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Maastricht, Netherlands

[4] Maastricht Univ, Dept Social Med, Maastricht, Netherlands

[5] Maastricht Univ, Dept Nutr & Movement Sci, Maastricht, Netherlands

[6] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands

[7] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands

[8] Maastricht Univ, MHeNS Sch Mental Hlth & Neurosci, Maastricht, Netherlands

[9] Maastricht Univ, Heart & Vasc Ctr, Med Ctr, Maastricht, Netherlands

[10] Maastricht Univ, Dept Complex Genet & Epidemiol, Maastricht, Netherlands

来源：

DIABETOLOGIA | 2022年 / 65卷 / 05期

关键词：

Cohort study; Diabetes mellitus type 2; Endothelial dysfunction; Low-grade inflammation; Physical activity; Sedentary behaviour; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MARKERS; EXERCISE; TIME; ATHEROSCLEROSIS; MECHANISMS; OVERWEIGHT; MORTALITY;

D O I：

10.1007/s00125-022-05651-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be especially prominent in type 2 diabetes. Methods In the population-based Maastricht Study (n = 2363, 51.5% male, 28.3% type 2 diabetes, 15.1% prediabetes [defined as impaired glucose tolerance and impaired fasting glucose]), we determined biomarkers of endothelial dysfunction and low-grade inflammation, and combined z scores were calculated. Physical activity and sedentary behaviour were measured by activPAL. Linear regression analyses were used with adjustment for demographic, lifestyle and cardiovascular risk factors. Results The association between total, light, moderate-to-vigorous and vigorous intensity physical activity and sedentary time on the one hand and biomarkers of endothelial dysfunction on the other were generally significant and were consistently stronger in prediabetes and type 2 diabetes as compared with normal glucose metabolism status (p for interaction <0.05). Associations between physical activity and sedentary behaviour on the one hand and low-grade inflammation on the other were also significant and were similar in individuals with and without (pre)diabetes (p for interaction >0.05). Conclusions/interpretation Physical activity and sedentary behaviour are associated with biomarkers of endothelial dysfunction and low-grade inflammation. For biomarkers of endothelial dysfunction, associations between physical activity and sedentary behaviour were consistently stronger in (pre)diabetes than in normal glucose metabolism. Whether increasing physical activity or decreasing sedentary time can positively influence biomarkers of endothelial dysfunction in individuals with prediabetes and type 2 diabetes requires further study.

引用

页码：777 / 789

页数：13

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