Nanodendritic gold/graphene-based biosensor for tri-mode miRNA sensing

被引:70
|
作者
Song, Yongchao [1 ]
Xu, Tailin [1 ]
Xu, Li-Ping [1 ]
Zhang, Xueji [1 ]
机构
[1] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
SURFACE; FLUORESCENT; PLATFORM; WETTABILITY; DEVICE;
D O I
10.1039/c8cc09586h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A nanodendritic gold/graphene-based biosensor that can perform fluorescence, SERS and electrochemical tri-modal miRNA detection in a single microdroplet has been developed. The biosensor was used to successfully perform tri-modal quantitative trace miRNA-375 detection, which enormously reduces false positive readings caused by interference and ambiguous signals, and has significant implications for use in precise physiological and pathological diagnosis.
引用
收藏
页码:1742 / 1745
页数:4
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