Non-thermal plasma combined with activated carbon was used as a method to purify wastewater of paracetamol factory. The effect of discharge time, discharge voltage, initial pH value of wastewater, velocity of the air flow and whether adding activated carbon on the COD degradation and decolorization ratio were investigated. The results show that with increasing of discharge time decolorization ratio decreased but the COD degradation ratio increase firstly and then tend to one constant value. The degradation ratio of COD increased and the decolorization decreased with the increasing of input voltage. The ratios of COD degradation and decolorization decreased with the initial pH value increased. With the increasing of inputting air flow the COD degradation ratio increases and have a optimal peak value and then the decolorization ratio decreases. With activated carbon adding the ratio of decolorization and the COD degradation can be improved significantly. In this paper when the input voltage is 25kV, distance between two electrodes 6mm, air flow 16L/h, initial pH value 3.73, the dilution wastewater of 4 times was discharged for 120min and then added 1g activated carbon, the ratio of COD degradation reached to 82.76%.