UV-VIS SPECTROPHOTOMETRY ANALYTICAL METHOD DEVELOPMENT FOR QUANTIFYING EFAVIRENZ.

被引：17

作者：

Santos Alves, Lariza Darlene ^{[1
]}

Rolim, Larissa Araujo ^{[1
]}

Ferreira Fontes, Danilo Augusto ^{[1
]}

Rolim-Neto, Pedro Jose ^{[1
]}

de La Roca Soares, Monica Felts ^{[2
]}

Soares Sobrinho, Jose Lamartine ^{[2
]}

机构：

[1] Univ Fed Pernambuco, Dept Ciencias Farmaceut, BR-50740521 Recife, PE, Brazil

[2] Univ Fed Piaui, Dept Bioquim & Farmacol, BR-64049550 Teresina, PI, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 09期

关键词：

UV-Vis spectroscopy; Efavirenz; analytical method; PERFORMANCE LIQUID-CHROMATOGRAPHY; REVERSE-TRANSCRIPTASE INHIBITOR; PLASMA; NEVIRAPINE; NELFINAVIR; AMPRENAVIR; VALIDATION; SAQUINAVIR; INDINAVIR; RITONAVIR;

D O I：

10.1590/S0100-40422010000900026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

UV-VIS SPECTROPHOTOMETRY ANALYTICAL METHOD DEVELOPMENT FOR QUANTIFYING EFAVIRENZ. An UV-Vis spectrophotometry analytical method for quantifying Efavirenz was developed and validated as an alternative to replace the HPLC current method. The report method presents sample concentration of 10 mu g mL(-1), dissolved in a solution ethanol:water (60:40, v/v), economic and technically adequate for the purpose adopted. The results and the statistical treated proved that the method beimg considered an precise and accurate analytical low cost alternative for laboratory routine. The adaptability of this method in product and other analytical methods development has been challenged by mathematical calculation of drug extinction coefficient in water and methanol and practical experiments, showing interesting results.

引用

页码：1967 / 1972

页数：6

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