Lipodystrophy and Insulin Resistance in Combination Antiretroviral Treated HIV-1-Infected Patients: Implication of Resistin

被引:19
|
作者
Escote, Xavier [2 ]
Miranda, Merce [2 ]
Veloso, Sergi
Domingo, Pere [3 ]
Alonso-Villaverde, Carlos [4 ]
Peraire, Joaquim
Vilades, Consuelo
Alba, Veronica
Olona, Montserrat
Castro, Antoni [4 ]
Lopez-Dupla, Miguel
Sirvent, Joan-Josep
Vicente, Vicente
Vendrell, Joan [2 ]
Richart, Cristobal
Vidal, Francesc [1 ]
机构
[1] Univ Rovira & Virgili, IISPV, Hosp Univ Tarragona Joan XXIII, Infect Dis & HIV AIDS Sect,Dept Internal Med, Tarragona 43007, Spain
[2] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona, Spain
[3] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, E-08193 Barcelona, Spain
[4] Univ Rovira & Virgili, IISPV, Hosp Univ St Joan, E-43201 Reus, Spain
关键词
HIV; combination antiretroviral therapy; lipodystrophy; resistin; insulin resistance; FASTING PLASMA-GLUCOSE; FAT REDISTRIBUTION; INNATE IMMUNITY; G/G GENOTYPE; POLYMORPHISM; THERAPY; OBESITY; RISK; PROMOTER; ADIPONECTIN;
D O I
10.1097/QAI.0b013e318213312c
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Little information is available with respect to the involvement of resistin in lipodystrophy and metabolic disturbances in HIV-1-infected patients treated with combination antiretroviral therapy (cART). We determined whether the resistin (rest) -420C>G single-nucleotide polymorphism and plasma resistin are associated with the development of lipodystrophy and metabolic disturbances in HIV-1-infected patients treated with cART. Methods: The study group comprised 299 HIV-1-infected patients treated with a stable cART for at least 1 year (143 with lipodystrophy and 156 without) and 175 uninfected controls. Anthropometric, clinical, and metabolic variables were determined. Homeostasis model assessment for insulin resistance was used to evaluate insulin resistance. Plasma resistin levels were determined by enzyme-linked immunosorbent assay. The rest -420>C. G was assessed using restriction fragment length polymorphism. Student t test, 1-way and 2-way analysis of variance, chi(2) test, and Pearson and Spearman correlations were performed for statistical analysis. Results: Genotypes containing the rest -420G variant allele were significantly more common in HIV-1-infected patients without lipodystrophy compared with those with lipodystrophy (P = 0.037). Infected patients had significantly greater plasma resistin levels than uninfected controls (P < 0.001). Among infected patients, plasma resistin levels were significantly lower in patients with lipodystrophy with respect to those without (P = 0.034). In infected patients, plasma resistin levels had a significant positive correlation with insulin and homeostasis model assessment for insulin resistance: P < 0.001 and P = 0.002 in the lipodystrophy subset and P = 0.002 and P = 0.03 in the nonlipodystrophy subset, respectively. Conclusions: In our cohort of white Spaniards, the rest -420>C. G single-nucleotide polymorphism may be associated with cART-related lipodystrophy. Plasma resistin correlates with insulin resistance in infected patients with and without lipodystrophy.
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页码:16 / 23
页数:8
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