The Helix Twist: Damage and Repair Follows the DNA Minor Groove

被引：1

作者：

Kotler, Eran ^{[1
,2
]}

Segal, Eran ^{[1
,2
]}

机构：

[1] Weizmann Inst Sci, Dept Comp Sci & Appl Math, IL-7610001 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Mol Cell Biol, IL-7610001 Rehovot, Israel

来源：

CELL | 2018年 / 175卷 / 04期

基金：

以色列科学基金会; 欧洲研究理事会;

关键词：

D O I：

10.1016/j.cell.2018.10.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a similar to 10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.

引用

页码：902 / 904

页数：3

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