itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens (vol 66, 103288, 2021)

被引:0
|
作者
Liesenborghs, Laurens [1 ,2 ]
Spriet, Isabel [3 ,4 ]
Jochmans, Dirk [1 ]
Belmans, Ann [5 ,6 ]
Gyselinck, Iwein [7 ,8 ]
Teuwen, Laure-Anne [9 ]
ter Horst, Sebastiaan [1 ]
Dreesen, Erwin [10 ]
Geukens, Tatjana [11 ]
Engelen, Matthias M. [12 ,13 ]
Landeloos, Ewout [14 ]
Geldhof, Vincent [9 ]
Ceunen, Helga [15 ,16 ]
Debaveye, Barbara [12 ,13 ]
Vandenberk, Bert [12 ,13 ]
Van der Linden, Lorenz [3 ,4 ]
Jacobs, Sofie [1 ]
Langendries, Lana [1 ]
Boudewijns, Robbert [1 ]
Do, Thuc Nguyen Dan [1 ]
Chiu, Winston [1 ]
Wang, Xinyu [1 ]
Zhang, Xin [1 ]
Weynand, Birgit [17 ]
Vanassche, Thomas [12 ,13 ]
Devos, Timothy [18 ,19 ]
Meyfroidt, Geert [13 ,20 ]
Janssens, Wim [7 ,8 ]
Vos, Robin [7 ,8 ]
Vermeersch, Pieter [21 ,22 ]
Wauters, Joost [16 ,23 ]
Verbeke, Geert [5 ,6 ]
De Munter, Paul [15 ,16 ]
Kaptein, Suzanne J. F. [1 ]
Rocha-Pereira, Joana [1 ]
Delang, Leen [1 ]
Van Wijngaerden, Eric [15 ,16 ]
Neyts, Johan [1 ]
Verhamme, Peter [12 ,13 ]
机构
[1] Katholieke Univ Leuven, Lab Virol & Chemotherapy, Dept Microbiol Immunol & Transplantat, Rega Inst Med Res, Leuven, Belgium
[2] Inst Trop Med, Outbreak Res Team, Dept Clin Sci, Antwerp, Belgium
[3] Katholieke Univ Leuven, Pharm Dept Univ Hosp Leuven, Leuven, Belgium
[4] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium
[5] KU Leuven Univ Leuven, Leuven, Belgium
[6] Univ Hasselt, I BioStat, Leuven, Belgium
[7] Katholieke Univ Leuven, Dept Resp Dis, UZ Leuven, Leuven, Belgium
[8] Katholieke Univ Leuven, CHROMETA, Res Grp BREATHE, Leuven, Belgium
[9] Katholieke Univ Leuven, Lab Angiogenesis & Vasc Metab, Ctr Canc Biol, VIB,Dept Oncol,Leuven Canc Inst, Leuven, Belgium
[10] Katholieke Univ Leuven, Clin Pharmacol & Pharmacotherapy Unit, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium
[11] Katholieke Univ Leuven, Dept Oncol, Lab Translat Breast Canc Res, Leuven, Belgium
[12] UZ, Dept Cardiovasc Sci, Leuven, Belgium
[13] Katholieke Univ Leuven, Leuven, Belgium
[14] VIB KU Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium
[15] Katholieke Univ Leuven, Dept Gen Internal Med, UZ Leuven, Leuven, Belgium
[16] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium
[17] Katholieke Univ Leuven, Translat Cell & Tissue Res, Dept Imaging & Pathol, Leuven, Belgium
[18] Katholieke Univ Leuven, Dept Hematol, UZ Leuven, Leuven, Belgium
[19] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Mol Immunol, Rega Inst, Leuven, Belgium
[20] UZ, Dept & Lab Intens Care Med, Leuven, Belgium
[21] Katholieke Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium
[22] Katholieke Univ Leuven, Dept Clin Lab Med, Leuven, Belgium
[23] Katholieke Univ Leuven, Med Intens Care Unit, Leuven, Belgium
来源
EBIOMEDICINE | 2021年 / 69卷
基金
欧盟地平线“2020”;
关键词
D O I
10.1016/j.ebiom.2021.103454
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial
    Liesenborghs, Laurens
    Spriet, Isabel
    Jochmans, Dirk
    Belmans, Ann
    Gyselinck, Iwein
    Teuwen, Laure-Anne
    ter Horst, Sebastiaan
    Dreesen, Erwin
    Geukens, Tatjana
    Engelen, Matthias M.
    Landeloos, Ewout
    Geldhof, Vincent
    Ceunen, Helga
    Debaveye, Barbara
    Vandenberk, Bert
    van der Linden, Lorenz
    Jacobs, Sofie
    Langendries, Lana
    Boudewijns, Robbert
    Do, Thuc Nguyen Dan
    Chiu, Winston
    Wang, Xinyu
    Zhang, Xin
    Weynand, Birgit
    Vanassche, Thomas
    Devos, Timothy
    Meyfroidt, Geert
    Janssens, Wim
    Vos, Robin
    Vermeersch, Pieter
    Wauters, Joost
    Verbeke, Geert
    De Munter, Paul
    Kaptein, Suzanne J. F.
    Rocha-Pereira, Joana
    Delang, Leen
    Van Wijngaerden, Eric
    Neyts, Johan
    Verhamme, Peter
    EBIOMEDICINE, 2021, 66
  • [2] Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial (vol 37, 100,959, 2021)
    Krolewiecki, Alejandro
    Lifschitz, Adrian
    Moragas, Matias
    Travacio, Marina
    Valentini, Ricardo
    Alonso, Daniel F.
    Solari, Ruben
    Tinelli, Marcelo A.
    Cimino, Ruben O.
    Alvarez, Luis
    Fleitas, Pedro E.
    Ceballos, Laura
    Golemba, Marcelo
    Fernandez, Florencia
    de Oliveira, Diego Fernandez
    Astudillo, German
    Baeck, Ines
    Farina, Javier
    Cardama, Georgina A.
    Mangano, Andrea
    Spitzer, Eduardo
    Gold, Silvia
    Lanusse, Carlos
    ECLINICALMEDICINE, 2021, 39
  • [3] The effects of urine alkalinization on kidney function in critically ill patients with COVID-19: a proof-of-concept randomized clinical trial
    Lumlertgul, Nuttha
    Kellum, John A.
    Powell-Tuck, Jonah
    Mathew, Moncy
    Sardiwal, Sunita
    Ostermann, Marlies
    INTENSIVE CARE MEDICINE EXPERIMENTAL, 2025, 13 (01):
  • [4] Machine learning is the key to diagnose COVID-19: a proof-of-concept study (vol 11, 7166, 2021)
    Gangloff, Cedric
    Rafi, Sonia
    Bouzille, Guillaume
    Soulat, Louis
    Cuggia, Marc
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [5] Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial
    Krolewiecki, Alejandro
    Lifschitz, Adrian
    Moragas, Matias
    Travacio, Marina
    Valentini, Ricardo
    Alonso, Daniel F.
    Solari, Ruben
    Tinelli, Marcelo A.
    Cimino, Ruben O.
    Alvarez, Luis
    Fleitas, Pedro E.
    Ceballos, Laura
    Golemba, Marcelo
    Fernandez, Florencia
    de Oliveira, Diego Fernandez
    Astudillo, German
    Baeck, Ines
    Farina, Javier
    Cardama, Georgina A.
    Mangano, Andrea
    Spitzer, Eduardo
    Gold, Silvia
    Lanusse, Carlos
    ECLINICALMEDICINE, 2021, 37
  • [6] US201 Study: A Phase 2, Randomized Proof-of-Concept Trial of Favipiravir for the Treatment of COVID-19
    Finberg, Robert W.
    Ashraf, Madiha
    Julg, Boris
    Ayoade, Folusakin
    Marathe, Jai G.
    Issa, Nicolas C.
    Wang, Jennifer P.
    Jaijakul, Siraya
    Baden, Lindsey R.
    Epstein, Carol
    OPEN FORUM INFECTIOUS DISEASES, 2021, 8 (12):
  • [7] Effectiveness of a Videoconferencing-Delivered Psychological Intervention for Mental Health Problems during COVID-19: A Proof-of-Concept Randomized Clinical Trial
    Bryant, Richard A.
    Dawson, Katie S.
    Keyan, Dharani
    Azevedo, Suzanna
    Yadav, Srishti
    Tran, Jenny
    Rawson, Natasha
    Harvey, Samuel
    PSYCHOTHERAPY AND PSYCHOSOMATICS, 2022, 91 (01) : 63 - 72
  • [8] Machine learning is the key to diagnose COVID-19: a proof-of-concept study
    Cedric Gangloff
    Sonia Rafi
    Guillaume Bouzillé
    Louis Soulat
    Marc Cuggia
    Scientific Reports, 11
  • [9] Positive affect training to reduce mental health problems during the COVID-19 pandemic: a proof-of-concept randomised clinical trial
    Bryant, Richard
    Dawson, Katie
    Azevedo, Suzanna
    Yadav, Srishti
    Tran, Jenny
    Choi-Christou, Jasmine
    Andrew, Elpiniki
    Beames, Joanne
    Keyan, Dharani
    BMJ MENTAL HEALTH, 2023, 26 (01):
  • [10] A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study
    T. Vanassche
    M. M. Engelen
    Q. Van Thillo
    J. Wauters
    J. Gunst
    C. Wouters
    C. Vandenbriele
    S. Rex
    L. Liesenborghs
    A. Wilmer
    P. Meersseman
    G. Van den Berghe
    D. Dauwe
    G. Verbeke
    M. Thomeer
    T. Fivez
    D. Mesotten
    D. Ruttens
    L. Heytens
    I. Dapper
    S. Tuyls
    B. De Tavernier
    P. Verhamme
    Trials, 21