Development of a Continuous-Flow Microreactor for Asymmetric Epoxidation of Electron-Deficient Olefins

被引：11
|
作者：
Dai, Wen
Mi, Yuan
Lv, Ying
Shang, Sensen
Li, Guosong
Chen, Guangwen [1 ]
Gao, Shuang [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 16期
基金：
中国博士后科学基金;
关键词：
continuous flow; microreactor; asymmetric epoxidation; iron catalysis; electron-deficient olefins; biomimetic catalyst; HIGHLY STEREOSELECTIVE EPOXIDATION; ENANTIOSELECTIVE EPOXIDATION; HYDROGEN-PEROXIDE; ALPHA; BETA-UNSATURATED KETONES; CATALYSIS; ALKENES; OXIDATION; ORGANOCATALYSIS; COMPLEXES; SYSTEM;
D O I：
10.1055/s-0035-1561955
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric epoxidation of electron-deficient olefins catalyzed by a biomimetic iron complex in a continuous-flow microreactor is described. The reaction conducted in the microreactor is characterized by rapid (<4 min) epoxidation of trisubstituted enones in high yields (up to 90%) and excellent enantioselectivities (up to 92% ee); compared to its batchwise counterpart, the microreactor reaction also allows shorter reaction times, safer operation, and more precise control over the reaction conditions.
引用
收藏
页码：2653 / 2658
页数：6
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