PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

被引：33

作者：

Teles Ferreira, Joana ^{[1
,2
,3
,4
]}

Pina, Joao ^{[5
]}

Fontes Ribeiro, Carlos Alberto ^{[4
]}

Fernandes, Rosa ^{[4
,6
]}

Tome, Joao P. C. ^{[2
,3
,7
]}

Salome Rodriguez-Morgade, M. ^{[1
,8
,9
]}

Torres, Tomas ^{[1
,8
,9
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[2] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[3] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

[4] Univ Coimbra, Fac Med, IBILI, P-3000548 Coimbra, Portugal

[5] Univ Coimbra, Dept Chem, CQC, Coimbra, Portugal

[6] Univ Coimbra, IBILI, CNC, P-3004504 Coimbra, Portugal

[7] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Av Rovisco Pais, P-1049001 Lisbon, Portugal

[8] UAM, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain

[9] Inst Madrileno Estudios Avanzados IMDEA Nanocienc, C Faraday 9, Madrid 28049, Spain

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 29期

关键词：

SINGLET OXYGEN; GENERATION; ZINC; NANOPARTICLES; DERIVATIVES; COMPLEXES; PORPHYRIN;

D O I：

10.1039/c7tb00958e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Three ruthenium(II) phthalocyanines functionalized at their axial positions with 4-12 PEG chains bearing hydroxy, amino and ether terminal groups were synthesized and studied as PDT agents against bladder cancer cells. All three dyes displayed high singlet oxygen generation quantum yields in DMSO (Phi Delta = 0.76). The water-soluble Ru(L3)(2)Pc also shows high singlet oxygen quantum yields (Phi Delta = 0.48) in neat water. In vitro studies show that these complexes are accumulated in bladder cancer cells, are nontoxic PSs per se, and have high phototoxic efficiency.

引用

页码：5862 / 5869

页数：8

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