HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

被引：0

作者：

Mikasi, Sello Given ^{[1
]}

Isaacs, Darren ^{[2
]}

Ikomey, George Mondinde ^{[3
]}

Shimba, Henerico ^{[1
,4
]}

Cloete, Ruben ^{[3
]}

Jacobs, Graeme Brendon ^{[1
]}

机构：

[1] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Pathol, Div Med Virol, ZA-7505 Cape Town, South Africa

[2] Univ Western Cape, South African Natl Bioinformat Inst, South African Med Res Council, Bioinformat Unit, Cape Town, South Africa

[3] Univ Yaounde I, Fac Med & Biomed Sci, Ctr Study & Control Communicable Dis, Yaounde, Cameroon

[4] Bugando Med Ctr, Mwanza, Tanzania

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2021年 / 37卷 / 01期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

HIV-1; integrase; resistance; Cameroon; diversity; CRF02_AG; DOLUTEGRAVIR; RALTEGRAVIR;

D O I：

10.1089/aid.2020.0022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences have INSTI accessory RAMs. HIV-1 CRF02_AG was the predominant subtype (44.7%) in this study analyses. The occurrence of INSTI RAMs among the sequences at baseline needs to be monitored carefully.

引用

页码：54 / 56

页数：3

共 50 条

[1] An HIV-1 integrase genotype assay for the detection of drug resistance mutations
Hearps, Anna C.
Greengrass, Vicki
Hoy, Jennifer
Crowe, Suzanne M.
SEXUAL HEALTH, 2009, 6 (04) : 305 - 309
[2] E92A Is an Activity Recovery Mutation of HIV-1 Integrase Drug Resistance Mutation N155S
Li Shan
Liu Bin
Li Chun-Hua
Tan Jian-Jun
Zhang Xiao-Yi
Wang Cun-Xin
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 41 (05) : 472 - 479
[3] Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy
Acharya, Arpan
Tagny, Claude T.
Mbanya, Dora
Fonsah, Julius Y.
Nchindap, Emilienne
Kenmogne, Leopoldine
Jihyun, Ma
Njamnshi, Alfred K.
Kanmogne, Georgette D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (05)
[4] HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon
Mikasi, Sello Given
Gichana, Josiah Otwoma
Van der Walt, Cheri
Brado, Dominik
Obasa, Adetayo Emmanuel
Njenda, Duncan
Messembe, Martha
Lyonga, Emilia
Assoumou, Okomo
Cloete, Ruben
Ikomey, George Mondinde
Jacobs, Graeme Brendon
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2020, 36 (05) : 450 - 455
[5] Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor
HU JianPing1
2 Department of Chemistry & Life Sciences
Science in China(Series B:Chemistry), 2007, (05) : 665 - 674
[6] A Study on Drug Resistance Mechanism of HIV-1 Integrase Mutants by Molecular Modeling
Zhang Xiao-Yi
He Hong-Qiu
Liu Bin
Wang Cun-Xin
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 36 (05) : 592 - 600
[7] Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor
JianPing, Hu
Shan, Chang
WeiZu, Chen
CunXin, Wang
SCIENCE IN CHINA SERIES B-CHEMISTRY, 2007, 50 (05): : 665 - 674
[8] Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor
Hu J.
Chang S.
Chen W.
Wang C.
Science in China Series B: Chemistry, 2007, 50 (5): : 665 - 674
[9] First Report of Drug Resistance against HIV-1 Integrase Inhibitors in Iran
Gholami, Mohammad
Rouzbahani, Negin Hosseini
Taj, Leila
Tayeri, Katayoun
Seyedalinaghi, SeyedAhmad
Manshadi, Seyed Ali Dehghan
JOURNAL OF INTERNATIONAL TRANSLATIONAL MEDICINE, 2019, 7 (01): : 19 - 24
[10] Differences among HIV-1 subtypes in drug resistance against integrase inhibitors
Han, Ying-Shan
Mesplede, Thibault
Wainberg, Mark A.
INFECTION GENETICS AND EVOLUTION, 2016, 46 : 286 - 291

← 1 2 3 4 5 →