A multiple drug-resistant Streptococcus pneumoniae of serotype 15A occurring from serotype 19A by capsular switching

被引：7

作者：

Savinova, T. ^{[1
]}

Brzhozovskaya, E. ^{[1
]}

Shagin, D. ^{[2
,3
]}

Mikhaylova, Y. ^{[3
]}

Shelenkov, A. ^{[3
]}

Yanushevich, Y. ^{[3
]}

Mayanskiy, N. ^{[2
]}

机构：

[1] Natl Med Res Ctr Childrens Hlth, Lomonosovskiy Av 2a, Moscow, Russia

[2] Pirogov Russian Natl Res Med Univ, Ostrovitianova St 1, Moscow, Russia

[3] Cent Res Inst Epidemiol, Novogireevskaya St 3a, Moscow, Russia

来源：

VACCINE | 2020年 / 38卷 / 33期

关键词：

Streptococcus pneumoniae; Capsular switching; Multiple drug-resistant pneumococcus; Serotype; 15A; PNEUMOCOCCI; EVOLUTION;

D O I：

10.1016/j.vaccine.2020.05.075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus pneumoniae is a highly recombinogenic pathogen. The ability of pneumococci to acquire and incorporate exogenous DNA is an important evolutionary mechanism for adaptation to clinical interventions such as antibiotic therapy and vaccination. Herein, using whole genome sequencing we detected a multiple drug-resistant serotype 15A pneumococcus emerged by capsular switching from serotype 19A/ST276. The dissemination of recombinant multiple drug-resistant pneumococcal clones with nonvaccine type capsule is of concern and warrants thorough monitoring of serotype and genotype structure within pneumococcal populations. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：5114 / 5118

页数：5

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