Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier

被引：36
|
作者：
Hosokawa, Takafumi [1 ]
Nakajima, Hideto [1 ,2 ]
Doi, Yoshimitsu [1 ]
Sugino, Masakazu [1 ]
Kimura, Fumiharu [1 ]
Hanafusa, Toshiaki [1 ]
Takahashi, Toshiyuki [3 ]
机构：
[1] Osaka Med Coll, Dept Internal Med 1, Osaka 5688686, Japan
[2] Seikeikai Hosp, Dept Internal Med, Osaka 5900024, Japan
[3] Tohoku Univ, Grad Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 236卷 / 1-2期
关键词：
Neuromyelitis optica; MMP-9; Blood-brain barrier; IL-8; Multiple sclerosis; Anti-aquaporin-4; antibody; MULTIPLE-SCLEROSIS; GELATINASE-B; ANTI-AQUAPORIN-4; ANTIBODY; MATRIX METALLOPROTEINASES; AQUAPORIN-4; DIAGNOSTIC-CRITERIA; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; IN-VIVO; BIOLOGY;
D O I：
10.1016/j.jneuroim.2011.04.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
相关论文
共 50 条
  • [1] Increased Serum Matrix Metalloproteinase-9 in Neuromyelitis Optica; Implication of Disruption of Blood-Brain Barrier
    Hosokawa, Takafumi
    Nakajima, Hideto
    Doi, Yoshimitsu
    Sugino, Masakazu
    Kimura, Fumiharu
    Hanafusa, Toshiaki
    Takahashi, Toshiyuki
    NEUROLOGY, 2010, 74 (09) : A167 - A167
  • [2] Blood-Brain Barrier Disruption in Humans Is Independently Associated With Increased Matrix Metalloproteinase-9
    Barr, Taura L.
    Latour, Lawrence L.
    Lee, Kyung-Yul
    Schaewe, Timothy J.
    Luby, Marie
    Chang, George S.
    El-Zammar, Ziad
    Alam, Shaista
    Hallenbeck, John M.
    Kidwell, Chelsea S.
    Warach, Steven
    STROKE, 2010, 41 (03) : E123 - E128
  • [3] S-nitrosoglutathione prevents blood-brain barrier disruption associated with increased matrix metalloproteinase-9 activity in experimental diabetes
    Aggarwal, Aanchal
    Khera, Alka
    Singh, Inderjit
    Sandhir, Rajat
    JOURNAL OF NEUROCHEMISTRY, 2015, 132 (05) : 595 - 608
  • [4] White Matter Injury After Subarachnoid Hemorrhage Role of Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9
    Egashira, Yusuke
    Zhao, Hao
    Hua, Ya
    Keep, Richard F.
    Xi, Guohua
    STROKE, 2015, 46 (10) : 2909 - 2915
  • [5] Neutrophils mediate blood-brain barrier disruption in a rat model of neuromyelitis optica
    Winkler, A.
    Wrzos, C.
    Bennett, J. L.
    Stadelmann, C.
    MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 174 - 175
  • [6] Early activation of matrix metalloproteinase-9 is associated with blood-brain barrier disruption after photothrombotic cerebral ischemia in rats
    Piao, Min-Sheng
    Lee, Jung-Kil
    Park, Chun-Soon
    Ryu, Han-Seung
    Kim, Soo-Han
    Kim, Hyung-Seok
    ACTA NEUROCHIRURGICA, 2009, 151 (12) : 1649 - 1653
  • [7] Matrix Metalloproteinase-9 Deletion Attenuates Blood-Brain Barrier Disruption and Consequent Injury in White Matter After Subarachnoid Hemorrhage
    Egashira, Yusuke
    Hua, Ya
    Keep, Richard F.
    Xi, Guohua
    STROKE, 2015, 46
  • [8] Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion
    Fujimura, M
    Gasche, Y
    Morita-Fujimura, Y
    Massengale, J
    Kawase, M
    Chan, PH
    BRAIN RESEARCH, 1999, 842 (01) : 92 - 100
  • [9] Melatonin Preserves Blood-brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition
    Shaji, Chinchusha Anasooya
    Alluri, Himakarnika
    Wiggins-Dohlvik, Katie
    Beeram, Madhava R.
    Davis, Matthew L.
    Tharakan, Binu L.
    FASEB JOURNAL, 2016, 30
  • [10] Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition
    Alluri, Himakarnika
    Wilson, Rickesha L.
    Shaji, Chinchusha Anasooya
    Wiggins-Dohlvik, Katie
    Patel, Savan
    Liu, Yang
    Peng, Xu
    Beeram, Madhava R.
    Davis, Matthew L.
    Huang, Jason H.
    Tharakan, Binu
    PLOS ONE, 2016, 11 (05):
12345