RYI-018: A Monoclonal Antibody Cannabinoid Receptor 1 Inverse Agonist For The Treatment of Metabolic Diseases

被引：0
|
作者：
Kretz-Rommel, Anke [1 ]
Ferrini, Roger [1 ]
Mann, Derek [2 ]
Shi, Lei [3 ]
Yang, Teddy [3 ]
Glicklich, Alan [1 ]
Grayson, Paul [1 ]
机构：
[1] Bird Rock Bio Inc, La Jolla, CA USA
[2] Newcaste Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
[3] RuiYi, Shanghai, Peoples R China
来源：
HEPATOLOGY | 2016年 / 64卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1153
引用
下载
收藏
页码：581A / 581A
页数：1
相关论文
共 50 条
  • [1] Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018
    Finlay, David B.
    Thuy Nguyen
    Gamage, Thomas F.
    Chen, Shuli
    Barrus, Daniel G.
    Patel, Purvi R.
    Thomas, Brian F.
    Wiley, Jenny L.
    Zhang, Yanan
    Glass, Michelle
    PHARMACOLOGY RESEARCH & PERSPECTIVES, 2022, 10 (01):
  • [2] A Novel Monoclonal Antibody Against Cannabinoid Receptor 1
    Kuang, Xinglin
    Liu, Yanjun
    Chen, Yilan
    Luo, Zhijuan
    Wei, Dapeng
    Bi, Jianhong
    Zhang, Chongjie
    HYBRIDOMA, 2012, 31 (02): : 131 - 136
  • [3] The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity
    Hagmann, William K.
    ARCHIV DER PHARMAZIE, 2008, 341 (07) : 405 - 411
  • [4] Taranabant, a novel cannabinoid type 1 receptor inverse agonist
    Fremming, Bradley A.
    Boyd, Steven T.
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2008, 9 (10) : 1116 - 1129
  • [5] Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity
    Chen, Chun-Rong
    McLachlan, Sandra M.
    Rapoport, Basil
    ENDOCRINOLOGY, 2007, 148 (05) : 2375 - 2382
  • [6] MEDI 471-Discovery of a novel cannabinoid-1 receptor inverse agonist for the treatment of obesity
    Hagmann, William K.
    Lin, Linus S.
    Lanza, Thomas J.
    Jewell, James P.
    Liu, Ping
    Shah, Shrenik K.
    Quang Truong
    Qi, Hongbo
    Guthikonda, Ravindra N.
    Chang, Linda L.
    Wilson, Jonathan
    Armstrong, Helen
    Kopka, Ihor E.
    Li, Bing
    Quaker, Grace
    Galka, Amy
    Tong, Xinchun
    Wang, Junying
    Xu, Sherry
    Fong, Tung M.
    Shen, Chun-Pyn
    Lao, Julie
    Chen, Jing
    Shearman, Lauren P.
    Stribling, D. Sloan
    Rosko, Kimberly
    Strack, Alison
    Marsh, Donald J.
    Feng, Yue
    Kumar, Sanjeev
    Samuel, Koppara
    Yin, Wenji
    Van der Ploeg, Lex H. T.
    Goulet, Mark T.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [7] An aromatic microdomain at the cannabinoid CB1 receptor constitutes an agonist/inverse agonist binding region
    McAllister, SD
    Rizvi, G
    Anavi-Goffer, S
    Hurst, DP
    Barnett-Norris, J
    Lynch, DL
    Reggio, PH
    Abood, ME
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (24) : 5139 - 5152
  • [8] Catalytic, enantioselective synthesis of taranabant, a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity
    Chen, Cheng-yi
    Frey, Lisa F.
    Shultz, Scott
    Wallace, Debra J.
    Marcantonio, Karen
    Payack, Joeseph F.
    Vazquez, Enrique
    Springfield, Shawn A.
    Zhou, George
    Liu, Ping
    Kieczykowski, Gerard R.
    Chen, Alex M.
    Phenix, Brian D.
    Singh, Utpal
    Strine, Jeff
    Izzo, Brianne
    Krska, Shane W.
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2007, 11 (03) : 616 - 623
  • [9] Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin
    Jules I. Schwartz
    Stephanie Dunbar
    Jinyu Yuan
    Susie Li
    Adrianna Gipson
    Kim Rosko
    Amy O. Johnson-Levonas
    Kenneth C. Lasseter
    Carol Addy
    Aubrey S. Stoch
    John A. Wagner
    Advances in Therapy, 2008, 25 : 1175 - 1190
  • [10] SR141716A is an inverse agonist at the human cannabinoid CB1 receptor
    Landsman, RS
    Burkey, TH
    Consroe, P
    Roeske, WR
    Yamamura, HI
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 334 (01) : R1 - R2
12345