Actin-binding toxin "tail" wags the dog

被引：4
|
作者：
Tanaka, Junichi [2 ]
Blain, J. Craig [1 ]
Allingham, John S. [1 ]
机构：
[1] Queens Univ, Dept Biochem, Kingston, ON K7L 3N6, Canada
[2] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan
来源：
CHEMISTRY & BIOLOGY | 2008年 / 15卷 / 03期
关键词：
D O I：
10.1016/j.chembiol.2008.02.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Actin-binding marine macrolides exhibit significant structural and functional diversity. In this issue, Perrins et al. demonstrate that a long stereochemically conserved aliphatic side chain, known as the "tail", found in many of these compounds is the functional determinant of cytotoxicity (Perrins et al., 2008).
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页码：205 / 207
页数：3
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