Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30

被引：7
|
作者：
Su, Xiao-Zheng [1 ,2 ]
Zhu, Yi-Ying [1 ]
Tang, Jian-Wei [1 ]
Hu, Kun [1 ]
Li, Xiao-Nian [1 ]
Sun, Han-Dong [1 ]
Li, Yan [1 ]
Puno, Pema-Tenzin [1 ]
机构：
[1] Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2020年 / 63卷 / 09期
基金：
中国国家自然科学基金;
关键词：
alkaloids; endophytic fungus; structure elucidation; tumor immunotherapy; IMMUNOTHERAPY; LIGANDS;
D O I：
10.1007/s11426-020-9762-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pestaloamides A and B (1 and 2), two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone] scaffold, were obtained from the cultures of an endophytic fungus Pestalotiopsis sp. HS30 which inhabited the stems of Isodon xerophilus. Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography. In addition, both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2D ligands involving MICA/B and ULBP1 in HCT116 cells.
引用
收藏
页码：1208 / 1213
页数：6
相关论文
共 26 条
  • [1] Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30
    XiaoZheng Su
    YiYing Zhu
    JianWei Tang
    Kun Hu
    XiaoNian Li
    HanDong Sun
    Yan Li
    PemaTenzin Puno
    Science China(Chemistry), 2020, 63 (09) : 1208 - 1213
  • [2] Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30
    Xiao-Zheng Su
    Yi-Ying Zhu
    Jian-Wei Tang
    Kun Hu
    Xiao-Nian Li
    Han-Dong Sun
    Yan Li
    Pema-Tenzin Puno
    Science China(Chemistry), 2020, (09) : 1208 - 1213
  • [3] Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30
    Xiao-Zheng Su
    Yi-Ying Zhu
    Jian-Wei Tang
    Kun Hu
    Xiao-Nian Li
    Han-Dong Sun
    Yan Li
    Pema-Tenzin Puno
    Science China Chemistry, 2020, 63 : 1208 - 1213
  • [4] Benzophenone derivatives from the plant endophytic fungus, Pestalotiopsis sp.
    Song, Ren-Yu
    Liu, Yi
    Liu, Rui-Huan
    Wang, Xiao-Bing
    Li, Tian-Xiao
    Kong, Ling-Yi
    Yang, Ming-Hua
    PHYTOCHEMISTRY LETTERS, 2017, 22 : 189 - 193
  • [5] Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp isolated from the Chinese mangrove plant Rhizophora mucronata
    Xu, Jing
    Kjer, Julia
    Sendker, Jandirk
    Wray, Victor
    Guan, Huashi
    Edrada, RuAngelie
    Mueller, Werner E. G.
    Bayer, Mirko
    Lin, Wenhan
    Wu, Jun
    Proksch, Peter
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (20) : 7362 - 7367
  • [6] Two New Pyrone Derivatives from the Plant Endophytic Fungus Exserohilum sp.
    Li, Ruxin
    Niu, Shubin
    Guo, Liangdong
    Zhang, Yang
    NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (10) : 1497 - 1498
  • [7] Two new polyketides from endophytic fungus Pestalotiopsis sp. HQD-6 isolated from the Chinese mangrove plant Rhizophora mucronata
    Zhou, Jing
    Zheng, Dong-Yao
    Xu, Jing
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24 (01) : 52 - 58
  • [8] Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101
    Xu, Zhiyong
    Wu, Xi
    Li, Gang
    Feng, Zhao
    Xu, Jing
    NATURAL PRODUCT RESEARCH, 2020, 34 (07) : 1002 - 1007
  • [9] Seimisochromenes A and B: two new dihydroisochromenes from the endophytic fungus, Seimatosporium sp.
    Hussain, Hidayat
    Jabeen, Farah
    Al-Harrasi, Ahmed
    Ahmad, Manzoor
    Mabood, Fazal
    Hussain, Javid
    Shah, Afzal
    Hassan, Zahid
    Rehman, Najeeb Ur
    Green, Ivan R.
    Khan, Amjad
    Dzeha, Thomas
    Draeger, Siegfried
    Schulz, Barbara
    Krohn, Karsten
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 17 (04) : 348 - 351
  • [10] Arthrinins EG, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66
    Su, Xiao-Zheng
    Tang, Jian-Wei
    Hu, Kun
    Li, Xiao-Nian
    Sun, Han-Dong
    Puno, Pema-Tenzin
    NATURAL PRODUCTS AND BIOPROSPECTING, 2020, 10 (04) : 201 - 207
123