Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma

被引：21

作者：

Murphy, N. C. ^{[1
,2
]}

Scarlett, C. J. ^{[1
]}

Kench, J. G. ^{[1
]}

Sum, E. Y. M. ^{[3
]}

Segara, D. ^{[1
]}

Colvin, E. K. ^{[1
]}

Susanto, J. ^{[1
]}

Cosman, P. H. ^{[1
]}

Lee, C. -S ^{[2
,4
]}

Musgrove, E. A. ^{[1
]}

Sutherland, R. L. ^{[1
]}

Lindeman, G. J.

Henshall, S. M. ^{[1
]}

Visvader, J. E. ^{[3
]}

Biankin, A. V. ^{[1
,5
]}

机构：

[1] Garvan Inst Med Res, Canc Res Program, Pancreatic Canc Res Grp, Darlinghurst, NSW 2010, Australia

[2] Royal Prince Alfred Hosp, Dept Pathol Anat, Sydney, NSW 2050, Australia

[3] Westmead Hosp, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia

[4] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia

[5] Bankstown Hosp, Div Surg, Sydney, NSW 2200, Australia

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 98卷 / 03期

基金：

英国医学研究理事会;

关键词：

LMO4; prognosis; outcome; pancreatic cancer; surgical resection; therapeutic response;

D O I：

10.1038/sj.bjc.6604177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection, whereas the survival of those patients whose tumours had low or no LMO4 expression was not significantly different when resection was compared with operative biopsy alone.

引用

页码：537 / 541

页数：5

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